Stochastic sensors inspired by biology
Stochastic sensors inspired by biology
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DOI：
10.1038/35093038
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发表时间：
2001-09-13
期刊：
影响因子：
64.8
通讯作者：
Cremer, PS
中科院分区：
文献类型：
--
作者：
Bayley, H;Cremer, PS
感觉系统使用各种膜结合受体，包括响应离子通道，以区分大量刺激。在这里，我们描述了如何工程膜孔可以用来使快速和敏感的生物传感器与潜在的应用范围从生物战剂的检测到药物筛选。值得注意的是，在随机传感（一种单分子检测技术）中使用工程孔可以揭示分析物的身份及其浓度。
Sensory systems use a variety of membrane-bound receptors, including responsive ion channels, to discriminate between a multitude of stimuli. Here we describe how engineered membrane pores can be used to make rapid and sensitive biosensors with potential applications that range from the detection of biological warfare agents to pharmaceutical screening. Notably, use of the engineered pores in stochastic sensing, a single-molecule detection technology, reveals the identity of an analyte as well as its concentration.