Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study
Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study
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DOI：
10.1111/j.1399-3038.2009.00949.x
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发表时间：
2010-02-01
影响因子：
4.4
通讯作者：
Virtanen, Suvi M.
中科院分区：
文献类型：
--
作者：
Nwaru, Bright I.;Ahonen, Suvi;Virtanen, Suvi M.
检查母亲妊娠期间饮食对5岁以下子代过敏性致敏的影响。芬兰1型糖尿病预测和预防营养研究。一项基于人群的队列研究，随访5年。共有931名儿童与人类白细胞抗原赋予1型糖尿病的易感性，母亲怀孕食物频率问卷调查数据和过敏原特异性免疫球蛋白E测量在5年。在调整潜在混杂因素后，增加母亲食用柑橘类水果[比值比（OR）= 1.14，95%置信区间（CI）= 1.05-1.25]和水果总量（OR = 1.36，95% CI = 1.09-1.70）与吸入性过敏原致敏呈正相关。母亲摄入维生素D（OR = 0.56，95%CI = 0.35-0.91）与食物过敏原致敏性呈负相关。母亲在怀孕期间食用柑橘类水果可能会增加后代过敏致敏的风险，而维生素D的摄入可能会产生有益的影响。需要进一步的研究，以更密切地确定母亲摄入多不饱和脂肪酸对后代过敏性疾病发展的推定影响。
To examine the effect of maternal diet during pregnancy on allergic sensitization in the offspring by 5 yrs of age. The Finnish type 1 Diabetes Prediction and Prevention Nutrition Study. A population-based cohort study with 5-yr follow-up. A total of 931 children with human leukocyte antigen-conferred susceptibility to type 1 diabetes for whom maternal pregnancy food frequency questionnaire data and allergen-specific immunoglobulin E measurement at 5 yrs were available. Increasing maternal consumption of citrus fruits [odds ratio (OR) = 1.14, 95% confidence interval (CI) = 1.05-1.25] and total fruit (OR = 1.36, 95% CI = 1.09-1.70) were positively associated with sensitization to inhalant allergens, after adjustment for potential confounders. Maternal intake of vitamin D (OR = 0.56, 95% CI = 0.35-0.91) was inversely associated with sensitization to food allergens. Maternal consumption of citrus fruits during pregnancy may increase the risk to allergic sensitization in the offspring, whereas vitamin D intake may have a beneficial effect. Further studies are required to define more closely the putative effect of maternal intake of polyunsaturated fatty acids on development of allergic diseases in the offspring.