Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice
Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice
复制标题
硫酸穿心莲内酯抑制 NF-κB 激活并减轻多聚 I:C 诱导的小鼠肺炎
DOI：
10.1016/j.jphs.2020.08.005
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发表时间：
2020-12-01
影响因子：
3.5
通讯作者：
Xu, Qiang
中科院分区：
文献类型：
--
作者：
Cui, Jian;Gao, Jian;Xu, Qiang
肺炎是一种常见的疾病，仍然是主要的杀手，仍然是患者人群发病率和死亡率的重要来源。许多微生物引起肺炎，现在关注的焦点转向了病毒性肺炎的新疗法。本文报道了穿心莲内酯的水溶性形式穿心莲内酯磺酸盐（商品名：喜炎平注射液）对聚I：C诱导的肺炎的影响。腹腔注射穿心莲内酯磺酸钠对poly I：C诱导的小鼠肺炎模型进行治疗。穿心莲内酯磺酸钠可明显减轻Poly I：C所致的气道炎症细胞聚集和肺组织学改变。穿心莲内酯磺酸钠治疗可降低支气管肺泡液（BALF）和血清中促炎细胞因子的蛋白水平。肺组织中MUC 5AC和MUC 5 B的水平也受到抑制。这些结果表明，硫酸穿心莲内酯对poly I：C诱导的小鼠肺炎有明显的缓解作用。此外，穿心莲内酯磺酸盐显著抑制核因子-κ B（NF-κ B）的活化。综上所述，我们证明了穿心莲磺酸盐改善聚I：C诱导的小鼠肺炎，表明穿心莲磺酸盐在临床上可能用于病毒诱导的肺炎。(C)2020年，任作家。Elsevier B. V.代表日本药理学会制作和主办。这是一个CC BY-NC-ND许可下的开放获取文章。
Pneumonia is a common illness that continues to be the major killer of remaining to be a significant source of morbidity and mortality in the patient population. Many microorganisms cause pneumonia, and now concern is turning to the importance of the cause the new therapies for viral pneumonia. In the current study, we report the effect of andrographolide sulfonate, a water-soluble form of andrographolide (trade name: Xi-Yan-Ping Injection), on poly I: C-induced pneumonia. Andrographolide sulfonate was administrated through intraperitoneal injection to mice with poly I: C-induced pneumonia. Recruitment of airway inflammatory cells, alteration of lung histological induced by Poly I: C were significantly ameliorated by andrographolide sulfonate. The protein levels of pro-inflammatory cytokines in bronchoalveolar fluid ( BALF) and serum were reduced by andrographolide sulfonate treatment. The levels of MUC5AC and MUC5B in lung tissue were also suppressed. These results reveal that andrographolide sulfate remarkably alleviated pneumonia induced by poly I:C in mice. Moreover, andrographolide sulfonate markedly inhibited the activation of nuclear factor-kappa B (NF-kappa B). Taken together, we demonstrated that andrographolide sulfonate ameliorated poly I: C-induced pneumonia in mice, suggesting the possible use of andrographolide sulfonate for virus-induced pneumonia in clinical. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license.