Increased fetal adiposity: A very sensitive marker of abnormal in utero development
Increased fetal adiposity: A very sensitive marker of abnormal in utero development
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DOI：
10.1016/s0002-9378(03)00828-7
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发表时间：
2003-12-01
影响因子：
9.8
通讯作者：
Amini, SB
中科院分区：
文献类型：
--
作者：
Catalano, PM;Thomas, A;Amini, SB
目的：由于妊娠期糖尿病妇女的后代在青壮年患肥胖症和糖尿病的风险增加，我们的目的是了解妊娠期糖尿病和正常糖耐量妇女婴儿出生时的身体组成特征。结果：两组新生儿出生体重(妊娠期糖尿病[3398+/-550 g]vs正常糖耐量[3337+/-549 g]，P=.26)或无脂肪体重(妊娠期糖尿病[2962+/-405 g]vs正常糖耐量[2975+/-408 g]，P=.74)无显著差异。然而，与糖耐量正常的孕妇的婴儿相比，妊娠期糖尿病妇女的婴儿的皮褶测量(P=.0001)和脂肪质量(妊娠期糖尿病[436+/-206g]vs正常糖耐量[362+/-198g]，P=.0002)显著增加。在妊娠期糖尿病组中，虽然胎龄与出生体重和脱脂体重的相关性最强，但空腹血糖水平与新生儿肥胖的相关性最强。结论：妊娠期糖尿病患者的婴儿即使在胎龄平均体重的情况下，也比糖耐量正常的婴儿体脂增加。孕妇空腹血糖水平是妊娠期糖尿病孕妇婴儿脂肪量的最强预测因子。这种身体脂肪的增加可能是儿童早期肥胖的一个重要风险因素，可能在以后的生活中也是如此。(Am J Obstet Gyneol 2003；189：1698-704。)
OBJECTIVE: Because offspring of women with gestational diabetes mellitus have an increased risk of obesity and diabetes mellitus as young adults, our purpose was to characterize body composition at birth in infants of women with gestational diabetes mellitus and normal glucose tolerance.STUDY DESIGN: One hundred ninety-five infants of women with gestational diabetes mellitus and 220 infants of women with normal glucose tolerance had anthropometric measurements and total body electrical conductivity body composition evaluations at birth. Parental demographic, anthropometric, medical and family history data, and diagnostic glucose values were used to develop a stepwise regression model that related to fetal growth and body composition.RESULTS: There was no significant difference in birth weight (gestational diabetes mellitus [3398 +/- 550 g] vs normal glucose tolerance [3337 +/- 549 g], P =.26) or fat-free mass (gestational diabetes mellitus [2962 +/- 405 g] vs normal glucose tolerance [2975 +/- 408 g], P =.74) between groups. However, infants of women with gestational diabetes mellitus had significantly greater skinfold measures (P =.0001) and fat mass (gestational diabetes mellitus [436 +/- 206 g] vs normal glucose tolerance [362 +/- 198 g], P =.0002) compared with infants of women with normal glucose tolerance. In the gestational diabetes mellitus group, although gestational age had the strongest correlation with birth weight and fat-free mass, fasting glucose level had the strongest correlation with neonatal adiposity.CONCLUSION: Infants of women with gestational diabetes mellitus, even when they are average weight for gestational age, have increased body fat compared with infants of women with normal glucose tolerance. Maternal fasting glucose level was the strongest predictor of fat mass in infants of women with gestational diabetes mellitus. This increase in body fat may be a significant risk factor for obesity in early childhood and possibly in later life. (Am J Obstet Gynecol 2003;189:1698-704.)