Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation.
Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation.
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在机械力相关的慢性炎症中，PIEZO1通道作为力传感器。
DOI：
10.3389/fimmu.2022.816149
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发表时间：
2022
影响因子：
7.3
通讯作者：
Hua F
中科院分区：
文献类型：
--
作者：
Liu H;Hu J;Zheng Q;Feng X;Zhan F;Wang X;Xu G;Hua F
机械损伤是炎症的诱发因素之一，贯穿整个炎症病理过程。反复或持续的破坏性机械刺激会导致慢性炎症性疾病。机械力如何诱发炎症的机制尚不完全清楚。 Piezo1是新发现的机械敏感离子通道。 Piezo1 通道响应机械刺激而打开，将机械信号转换为细胞内的炎症级联反应，导致组织炎症。大量证据表明Piezo1在慢性炎症性疾病的发生和进展中发挥着至关重要的作用。这篇小综述简要介绍了 Piezo1 对不同机械应力做出反应以引发各种组织炎症的新证据。 Piezo1的发现为治疗与机械应力相关的慢性炎症性疾病提供了新的见解。抑制损伤性机械信号向炎症信号的转导可以抑制炎症并在早期阶段改善炎症的结果。 Piezo1的药理学显示出广阔的前景。开发用于临床的组织特异性Piezo1药物可能成为治疗慢性炎症的新靶点。
Mechanical damage is one of the predisposing factors of inflammation, and it runs through the entire inflammatory pathological process. Repeated or persistent damaging mechanical irritation leads to chronic inflammatory diseases. The mechanism of how mechanical forces induce inflammation is not fully understood. Piezo1 is a newly discovered mechanically sensitive ion channel. The Piezo1 channel opens in response to mechanical stimuli, transducing mechanical signals into an inflammatory cascade in the cell leading to tissue inflammation. A large amount of evidence shows that Piezo1 plays a vital role in the occurrence and progression of chronic inflammatory diseases. This mini-review briefly presents new evidence that Piezo1 responds to different mechanical stresses to trigger inflammation in various tissues. The discovery of Piezo1 provides new insights for the treatment of chronic inflammatory diseases related to mechanical stress. Inhibiting the transduction of damaging mechanical signals into inflammatory signals can inhibit inflammation and improve the outcome of inflammation at an early stage. The pharmacology of Piezo1 has shown bright prospects. The development of tissue-specific Piezo1 drugs for clinical use may be a new target for treating chronic inflammation.