Differential Effects of Transcranial Static Magnetic Stimulation Over Left and Right Dorsolateral Prefrontal Cortex on Brain Oscillatory Responses During a Working Memory Task
Differential Effects of Transcranial Static Magnetic Stimulation Over Left and Right Dorsolateral Prefrontal Cortex on Brain Oscillatory Responses During a Working Memory Task
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DOI：
10.1016/j.neuroscience.2023.03.006
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发表时间：
2023-03-20
期刊：
影响因子：
3.3
通讯作者：
Kirimoto，Hikari
中科院分区：
文献类型：
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作者：
Watanabe，Tatsunori;Chen，Xiaoxiao;Kirimoto，Hikari
已知经颅静态磁刺激（tSMS）会影响行为和神经活动。然而，尽管左和右背外侧前额叶皮层（DLPFC）与不同的认知功能相关，但仍然缺乏关于tSMS对左和右DLPFC刺激之间的认知表现和相关大脑活动的影响差异的知识。为了解决这一知识差距，我们研究了不同的tSMS左右DLPFC改变工作记忆的性能和脑电图振荡反应使用2回任务，其中受试者监测一系列的刺激，并决定是否呈现的刺激匹配的刺激提出了两个试验之前。14名健康成年人（5名女性）在三种不同刺激条件（左侧DLPFC上的tSMS、右侧DLPFC上的tSMS和假刺激）之前、期间（刺激开始后20分钟）、之后立即和之后15分钟进行2-back任务。我们的初步研究结果表明，虽然tSMS在左和右DLPFC损害工作记忆的表现在相似的程度，tSMS对脑振荡反应的影响是不同的左和右DLPFC刺激。具体而言，tSMS在左侧DLPFC增加了β带中的事件相关同步，而tSMS在右侧DLPFC上没有显示出这种效果。这些发现支持证据表明，左和右DLPFC在工作记忆中发挥不同的作用，并表明，潜在的神经机制的损害工作记忆的tSMS可以是不同的左和右DLPFC之间的刺激。
Transcranial static magnetic stimulation (tSMS) is known to influence behavioral and neural activities. However, although the left and right dorsolateral prefrontal cortex (DLPFC) are associated with different cognitive functions, there remains a lack of knowledge on a difference in the effects of tSMS on cognitive performance and related brain activity between left and right DLPFC stimulations. To address this knowledge gap, we examined how differently tSMS over the left and right DLPFC altered working memory performance and electroencephalographic oscillatory responses using a 2-back task, in which subjects monitor a sequence of stimuli and decide whether a presented stimulus matches the stimulus presented two trials previously. Fourteen healthy adults (five females) performed the 2-back task before, during (20 min after the start of stimulation), immediately after, and 15 min after three different stimulation conditions: tSMS over the left DLPFC, tSMS over the right DLPFC, and sham stimulation. Our preliminary results revealed that while tSMS over the left and right DLPFC impaired working memory performance to a similar extent, the impacts of tSMS on brain oscillatory responses were different between the left and right DLPFC stimulations. Specifically, tSMS over the left DLPFC increased the event-related synchronization in beta band whereas tSMS over the right DLPFC did not show such an effect. These findings support evidence that the left and right DLPFC play different roles in working memory and suggest that the neural mechanism underlying the impairment of working memory by tSMS can be different between left and right DLPFC stimulations.