ROLE OF FGFS IN SKELETAL-MUSCLE AND LIMB DEVELOPMENT
ROLE OF FGFS IN SKELETAL-MUSCLE AND LIMB DEVELOPMENT
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DOI：
10.1002/mrd.1080390114
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发表时间：
1994-09-01
影响因子：
2.5
通讯作者：
KUDLA, AJ
中科院分区：
文献类型：
--
作者：
OLWIN, BB;ARTHUR, K;KUDLA, AJ
成纤维细胞生长因子（FGF）是与三种不同类型的细胞表面分子结合的九种蛋白质的家族：（i）FGF受体酪氨酸激酶（FGFR-1至FGFR-4）;（ii）富含半胱氨酸的FGF受体（CFR）;和（iii）硫酸乙酰肝素蛋白聚糖（HSPG）。FGF的信号传导需要这些受体中至少两种的参与：FGFR和HSPG形成信号传导复合物。硫酸乙酰肝素链的酸性硫酸化模式的长度决定了信号传导复合物的活性，并且部分地决定了FGFR-1的配体特异性。因此，硫酸乙酰肝素蛋白聚糖可能在信号传导中发挥重要作用。我们最近发现FGF在体内肢芽发育中的作用。在鸡肢芽中，FGF-2的18 kDa形式或在其氨基末端与人工信号肽融合的FGF-2的异位表达引起骨骼复制。这些数据以及FGF-2定位于早期发育肢体中的下中胚层和顶端外胚层嵴的观察结果表明，FGF-2在肢体生长中起重要作用。我们认为FGF-2是一种顶端外胚层嵴衍生因子，参与肢体生长和形成模式。(C)1994 Wiley-Liss，Inc.
Fibroblast growth factors (FGFs) are a family of nine proteins that bind to three distinct types of cell surface molecules: (i) FGF receptor tyrosine kinases (FGFR-1 through FGFR-4); (ii) a cysteine-rich FGF receptor (CFR); and (iii) heparan sulfate proteoglycans (HSPGs). Signaling by FGFs requires participation of at least two of these receptors: the FGFRs and HSPGs form a signaling complex. The length acid sulfation pattern of the heparan sulfate chain determines both the activity of the signaling complex and, in part, the ligand specificity for FGFR-1. Thus, the heparan sulfate proteoglycans are likely to play an essential role in signaling.We have recently identified a role for FGF in limb bud development in vivo. In the chick limb bud, ectopic expression of the 18 kDa form of FGF-2 or FGF-2 fused to an artificial signal peptide at its amino terminus causes skeletal duplications. These data, and the observations that FGF-2 is localized to the subjacent mesoderm and the apical ectodermal ridge in the early developing limb, suggest that FGF-2 plays an important role in limb outgrowth. We propose that FGF-2 is an apical ectodermal ridge-derived factor that participates in limb outgrowth and patterning. (C) 1994 Wiley-Liss, Inc.