Skin‐Inspired Porous Mesh Bioelectronics with Built‐In Multifunctionality for Concurrently Monitoring Heart Electrical and Mechanical Functions
Skin‐Inspired Porous Mesh Bioelectronics with Built‐In Multifunctionality for Concurrently Monitoring Heart Electrical and Mechanical Functions
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DOI：
10.1002/adfm.202302681
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发表时间：
2023-06
影响因子：
19
通讯作者：
Yun Ling;Ganggang Zhao;Yajuan Su;Qian Wu;Yadong Xu;Zehua Chen;Brian Arends;O. Emeje;
中科院分区：
文献类型：
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作者：
Yun Ling;Ganggang Zhao;Yajuan Su;Qian Wu;Yadong Xu;Zehua Chen;Brian Arends;O. Emeje;
皮肤表现出非线性力学，最初是柔软的，随着拉伸迅速变硬，以防止大变形引起的伤害。开发具有皮肤启发的非线性机械行为的皮肤界面生物电子器件，以及多种其他所需的功能（透气，抗菌和粘性），是可取的，但具有挑战性。在此，本研究报告的设计，制造和生物医学应用的多孔网生物电子，可以同时实现这些功能。一方面，在理论模拟的指导下设计和制造聚酰亚胺（PI）多孔蛇形补片，以提供皮肤样非线性力学和高透气性。另一方面，超软、粘性和抗菌的聚二甲基硅氧烷（PDMS）是通过对多聚赖氨酸（ε-PL）进行改性而开发的，这是目前该领域缺乏的。在这里，ε-PL-改性PDMS喷涂在PI补片上，形成核壳结构，而不会堵塞其孔隙，从而提供超软、粘性和抗菌的皮肤界面。合理设计的多孔混合网格不仅可以保持皮肤般的非线性力学性能，还可以集成各种医疗保健应用的软硬生物电子组件。作为范例，本研究将基于软银纳米线（AgNWs）的电生理传感器和刚性商业加速度计集成在多功能多孔网格上，用于同时监测心脏电和机械功能，以提供不断变化的心脏状态的全面信息。
Skin exhibits nonlinear mechanics, which is initially soft and stiffens rapidly as being stretched to prevent large deformation‐induced injuries. Developing skin‐interfaced bioelectronics with skin‐inspired nonlinear mechanical behavior, together with multiple other desired features (breathable, antibacterial, and sticky), is desirable yet challenging. Herein, this study reports the design, fabrication, and biomedical application of porous mesh bioelectronics that can simultaneously achieve these features. On the one hand, porous serpentine meshes of polyimide (PI) are designed and fabricated under the guidance of theoretical simulations to provide skin‐like nonlinear mechanics and high breathability. On the other hand, ultrasoft, sticky, and antibacterial polydimethylsiloxane (PDMS) is developed through epsilon polylysine (ε‐PL) modifications, which currently lacks in the field. Here, ε‐PL‐modified PDMS is spray‐coated on PI meshes to form the core–shell structures without blocking their pores to offer ultrasoft, sticky, and antibacterial skin interfaces. And rationally designed porous hybrid meshes can not only retain skin‐like nonlinear mechanical properties but also enable the integration of both soft and hard bioelectronic components for various healthcare applications. As the exemplar example, this study integrates soft silver nanowires (AgNWs) based electrophysiological sensors and rigid commercial accelerometers on multifunctional porous meshes for concurrently monitoring heart electrical and mechanical functions to provide the comprehensive information of the evolving heart status.