Bisphenol-A Concentrations from Leiomyoma Patients by LC/MS
Bisphenol-A Concentrations from Leiomyoma Patients by LC/MS
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DOI：
10.5487/tr.2011.27.1.049
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发表时间：
2011-03-01
影响因子：
2.3
通讯作者：
Kim, Jong Min
中科院分区：
文献类型：
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作者：
Han, Myoung Seok;Byun, Jae Chun;Kim, Jong Min
本研究的目的是调查有多少平滑肌瘤患者暴露于双酚A（BPA），一种内分泌干扰物，以及BPA的血清浓度是否与平滑肌瘤生长有关。最初，根据平滑肌瘤的大小，将128名患者分为一个对照组和三个平滑肌瘤组（轻度、中度和重度）。采用液相色谱-质谱联用法（LC/MS）测定血清BPA浓度。近三分之二的平滑肌瘤患者暴露于BPA，BPA的范围从未检测到2.603 ng/ml。各组的平均BPA浓度分别为1.015 +/- 0.775 ng/ml（对照组）、0.774 +/- 0.834 ng/ml（轻度）、1.261 +/- 0.797 ng/ml（中度）和1.244 +/- 0.860 ng/ml（重度）（p = 0.158）。在重新组合成两组后，第1组（对照加轻度）与第2组（中度加重度），在第2组中发现更高的水平，即使没有统计学意义（p = 0.06）。总之，大约三分之二的平滑肌瘤患者暴露于BPA，但它可能对平滑肌瘤没有生长促进作用。
The aim of this study is to investigate how many leiomyoma patients are exposed to bisphenol-A (BPA), an endocrine disruptor, and whether the serum concentration of BPA is related to leiomyoma growth. Initially, 128 patients were divided into one control and three leiomyoma groups (mild, moderate and severe) according to the size of the leiomyomas. Serum BPA concentrations were measured by liquid chromatography and mass spectrometry (LC/MS). Nearly two-thirds of leiomyoma patients were exposed to BPA and the range of BPA was from non-detection to 2.603 ng/ml. The mean BPA concentrations in the groups were 1.015 +/- 0.775 ng/ml (control), 0.774 +/- 0.834 ng/ml (mild), 1.261 +/- 0.797 ng/ml (moderate) and 1.244 +/- 0.860 ng/ml (severe) (p = 0.158). After recombination into two group, Group 1 (control plus mild) vs. Group 2 (moderate plus severe), higher level was found in Group 2 even with no statistical significance (p = 0.06). In conclusion, about two-thirds of leiomyoma patients were exposed to BPA, but it may not have growth promoting effect on leiomyoma.