The First Example of a Regioselective Biginelli-Like Reaction Based on 3-Alkylthio-5-amino-1,2,4-triazole
The First Example of a Regioselective Biginelli-Like Reaction Based on 3-Alkylthio-5-amino-1,2,4-triazole
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基于 3-烷硫基-5-氨基-1,2,4-三唑的区域选择性 Biginelli 类反应的第一个实例
DOI：
10.1002/jhet.1
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发表时间：
2009-03-01
影响因子：
2.4
通讯作者：
Yang, Guang-Fu
中科院分区：
文献类型：
--
作者：
Chen, Qiong;Jiang, Li-Li;Yang, Guang-Fu
研究了3-氨基-5-烷硫基-1，2，4-三唑与芳香醛和β-酮酸酯的三组分缩合反应。结果表明，反应溶剂和β-酮酯组分的性质对反应的区域选择性有很大影响。这是首次报道氨基三唑类Biginelli反应的区域选择性。
The three-component condensation of 3-amino-5-alkylthio-1,2,4-triazoles with aromatic aldehydes and beta-ketocster was studied to develop a regioselective Biginelli-like reaction. The results indicated that the reaction solvent and the properties of the beta-ketoester component displayed great influence on the regioselectivity. This is the first report about the regioselectivity of the aminotriazole-based Biginelli-like reaction.