Risk factors for non-sentinel lymph node metastases in patients with breast cancer. The outcome of a multi-institutional study
Risk factors for non-sentinel lymph node metastases in patients with breast cancer. The outcome of a multi-institutional study
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DOI：
10.1245/s10434-006-9065-1
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发表时间：
2007-01-01
影响因子：
3.7
通讯作者：
Tjan-Heijnen, Vivianne C. G.
中科院分区：
文献类型：
--
作者：
Bolster, Marieke J.;Peer, Petronella G. M.;Tjan-Heijnen, Vivianne C. G.
背景资料：在这项多机构前瞻性研究中，我们评估了我们是否可以识别出预测前哨淋巴结（SN）阳性的乳腺癌患者非前哨淋巴结（non-SN）转移的危险因素。方法：在这项多机构研究中，前瞻性纳入了541例符合条件的乳腺癌患者。非SN转移的发生与SN转移的大小（P = 0.02）、原发肿瘤大小（P = 0.001）和淋巴管浸润（P = 0.07）有关。SN微转移与SN分离的肿瘤细胞相比的调整优势比为3.1，SN大转移与SN分离的肿瘤细胞相比的调整优势比为4.0，肿瘤大小（> 3.0 cm与SN分离的肿瘤细胞相比）为3.1，
Background: In this multi-institutional prospective study, we evaluated whether we could identify risk factors predictive for non-sentinel lymph node (non-SN) metastases in breast cancer patients with a positive sentinel lymph node (SN).Methods: In this multi-institutional study, 541 eligible breast cancer patients were included prospectively.Results: The occurrence of non-SN metastases was related to the size of the SN metastasis (P = .02), primary tumor size (P = .001), and lymphovascular invasion (P = .07). The adjusted odds ratio was 3.1 for SN micro-metastasis compared with SN isolated tumor cells, 4.0 for SN macro-metastasis versus SN isolated tumor cells, 3.1 for tumor size (> 3.0 cm compared with