High-Q microsphere biosensor - analysis for adsorption of rodlike bacteria
High-Q microsphere biosensor - analysis for adsorption of rodlike bacteria
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DOI：
10.1364/oe.15.017410
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发表时间：
2007-12-10
期刊：
影响因子：
3.8
通讯作者：
Libchaber, Albert
中科院分区：
文献类型：
--
作者：
Ren, Hai-Cang;Vollmer, Frank;Libchaber, Albert
提出了杆状细菌在微光学谐振腔中引起的频率偏移和线宽展宽的理论。回音壁模式（WGMs）的光学位移建模，通过引入一个形状因子，占随机水平取向的圆柱形细菌约束其高折射率细胞壁。线宽展宽估计从散射损失。通过使用大肠杆菌作为模型系统（类似于10（2）个细菌/mm（2）灵敏度）的测量来确认分析结果，确立WGM生物传感器作为用于检测和分析微生物的灵敏技术。(c)2007年，美国光学学会。
Theory is developed for frequency shift and linewidth-broadening induced by rodlike bacteria bound to micro-optical resonators. Optical shift of whispering gallery modes (WGMs) is modeled by introducing a form factor that accounts for random horizontal orientation of cylindrical bacteria bound by their high refractive index cell walls. Linewidth-broadening is estimated from scattering losses. Analytic results are confirmed by measurement using E.Coli as model system (similar to 10(2) bacteria/mm(2) sensitivity), establishing the WGM biosensor as sensitive technique for detection and analysis of micro-organisms. (c) 2007 Optical Society of America.