RAT MUSCLE BLOOD FLOWS DURING HIGH-SPEED LOCOMOTION
RAT MUSCLE BLOOD FLOWS DURING HIGH-SPEED LOCOMOTION
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DOI：
10.1152/jappl.1985.59.4.1322
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
LAUGHLIN, MH
中科院分区：
文献类型：
--
作者：
ARMSTRONG, RB;LAUGHLIN, MH
我们之前研究了在电动跑步机上从步行(15m/min)到奔跑(75m/min)的速度对大鼠肌肉内和肌肉之间血流分布的影响。结果表明，当速度超过75m/min时，肌肉血流量随着速度的增加而继续增加。本研究的目的是让大鼠跑到跑步机的最大速度，以确定肌肉中的血液流动是否随着动物正常运动速度范围内的跑步速度而达到平台期。以75、90和105m/min的速度跑1min，用放射性标记微球测量大鼠的肌肉血流量。数据表明，即使在这些相对较高的跑步机速度下，仍然没有明显的证据表明大多数后肢肌肉的血流处于平台期。大多数肌肉中的流量随着速度的增加而继续增加。这些观察到的血流与跑步速度之间的模式可能是因为严格选择了能够进行高强度运动的大鼠，因此只代表了高度特定的动物种群。另一方面，这些数据可能被解读为表明，实验大鼠在运动过程中的心血管潜力比通常假设的要高得多，向肌肉输送的血液不足并不是它们运动能力的主要限制。
We previously studied blood flow distribution within and among rat muscles as a function of speed from walking (15 m/min) through galloping (75 m/min) on a motor-driven treadmill. The results showed that muscle blood flows continued to increase as a function of speed through 75 m/min. The purpose of the present study was to have rats run up to maximal treadmill speeds to determine if blood flows in the muscles reach a plateau as a function of running speed over the animals'' normal range of locomotory speeds. Muscle blood flows were measured with radiolabeled microspheres at 1 min of running at 75, 90, and 105 m/min in male Sprague-Dawley rats. The data indicate that even at these relatively high treadmill speeds there was still no clear evidence of a plateau in blood flow in most of the hindlimb muscles. Flows in most muscles continued to increase as a function of speed. These observed patterns of blood flow vs. running speed may have resulted from the rigorous selection of rats that were capable of performing the high-intensity exercise and thus only be representative of a highly specific population of animals. On the other hand, the data could be interpreted to indicate that the cardiovascular potential during exercise is considerably higher in laboratory rats than has normally been assumed and that inadequate blood flow delivery to the muscles does not serve as a major limitation to their locomotory performance.