Comparison of indices of premorbid function in schizophrenia.
Comparison of indices of premorbid function in schizophrenia.
复制标题
精神分裂症病前功能指标的比较。
DOI：
10.1016/0920-9964(94)e0057-e
复制
发表时间：
1995
影响因子：
4.5
通讯作者：
Kim,L
中科院分区：
文献类型：
--
作者：
DeQuardo,JR;Goldman,RS;Tandon,R;McGrath-Giroux,M;Kim,L
精神分裂症病前功能的研究重新引起了人们的兴趣，因为它为精神分裂症的发病和病因提供了线索。大多数研究依赖于不完整的病前状态的回顾性估计，例如病前适应量表（PAS）。即使是前瞻性的高风险研究也受到狭窄的病前功能评估范围的阻碍，因此无法回答与疾病发作相关的关键问题。本研究的目的是评估几个指标的病前功能之间的关系。对64例住院精神分裂症患者在治疗前和治疗后进行BPRS和SANS评定。PAS评分来自所有可用的来源。以WAIS-R词汇和信息分量表的平均值评估病前认知能力。使用人口统计学回归公式获得发病前的估计智商。研究发现，受教育年限和预测的VIQ、PIQ和FSIQ与估计的病前认知能力相关。预测的VIQ、PIQ和FSIQ与受教育年限、PAS儿童期、青春期早期和晚期以及总分相关。每一种病前能力的评估都表现出与临床评级、症状变化和结局相关的不同模式。结果表明，教育，PAS，预测智商，和WAIS-R估计的病前认知能力评估不同的，但重叠的领域的病前功能。
There has been a resurgence of interest in the area of premorbid functioning in schizophrenia as it provides clues to onset and etiology. Most studies rely on retrospective estimates of premorbid status that are incomplete, such as the Premorbid Adjustment Scale (PAS). Even prospective high-risk studies are hampered by the narrow range of premorbid functions assessed and are thus unable to answer crucial questions related to onset of illness. This study was undertaken to assess the relationship between several indices of premorbid functioning. Sixty four in-patients with schizophrenia were assessed at medication-free baseline and post-treatment with BPRS and SANS. PAS scores were derived from all available sources. Premorbid cognitive ability was estimated by the mean of WAIS-R Vocabulary and Information subscale scores. Estimated premorbid IQ was obtained using a demographic regression formula. Years of education and predicted VIQ, PIQ, and FSIQ were found to correlate with estimated premorbid cognitive ability. Predicted VIQ, PIQ, and FSIQ were associated with years of education and PAS childhood, early and late adolescence, and general scores. Each estimate of premorbid ability demonstrated a different pattern of association with clinical ratings, symptom change, and outcome. The results suggest that education, PAS, predicted IQ, and WAIS-R estimates of premorbid cognitive ability assess different but overlapping areas of pre-morbid functioning.