Adult glioma incidence trends in the United States, 1977-2000
Adult glioma incidence trends in the United States, 1977-2000
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DOI：
10.1002/cncr.20621
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发表时间：
2004-11-15
期刊：
影响因子：
6.2
通讯作者：
Bondy, ML
中科院分区：
文献类型：
--
作者：
Hess, KR;Broglio, KR;Bondy, ML
背景几位作者报道了脑肿瘤发病率的增加，特别是在老年人中。对成人胶质瘤发病趋势的更全面了解可能为胶质瘤的危险因素提供指征，并有助于寻求更好的治疗方法。作者使用了监测、流行病学和最终结果（SEER）登记处公共使用数据磁带，其中包括1973年至2000年间诊断出癌症的患者的数据。对于3种组织学以及12种组织学分类组合，作者使用泊松回归将发病率建模为诊断年份、诊断时年龄、人种（白色或非裔美国人）和性别的函数。他们使用三次样条来拟合诊断时的年龄和诊断年份，并测试了所有成对的相互作用。在所有四组模型中，诊断年份和诊断年龄之间的相互作用是显着的。在胶质母细胞瘤中，诊断时性别和年龄之间也存在显著的相互作用。在间变性星形细胞瘤中，性别和诊断年份之间存在显著的相互作用。在少突胶质细胞瘤中，种族和性别之间存在显著的相互作用。在12个组织学分类中，性别和诊断时的年龄之间存在显著的相互作用。当前研究的结果与其他已发表的报告一致，这些报告显示使用SEER数据的脑肿瘤发病率增加。尽管其他人已经观察到老年人的发病率呈上升趋势，但作者进行了正式测试，发现诊断时年龄和诊断年份之间存在统计学显着的相互作用。(C)2004年美国癌症协会。
BACKGROUND. Several authors have reported an increase in the incidence of brain tumors, especially among the elderly. A more complete understanding of adult glioma incidence trends might provide indications of risk factors for gliomas and contribute to the search for improved therapies.METHODS. The authors used the Surveillance, Epidemiology, and End Results (SEER) registry public use data tapes, which included data on patients with cancer diagnosed between 1973 and 2000. For 3 histologies as well as for 12 histology categories combined, the authors used Poisson regression to model incidence as a function of year of diagnosis, age at diagnosis, race (white or African American), and gender. They used cubic splines to fit age at diagnosis and year of diagnosis and tested for all pair-wise interactions.RESULTS. The interaction between year of diagnosis and age at diagnosis was significant in all four groups modeled. In glioblastoma, there was also a significant interaction between gender and age at diagnosis. In anaplastic astrocytoma, there was a significant interaction between gender and year of diagnosis. In oligodendroglioma, there was a significant interaction between race and gender. In the 12 histology categories combined, there was a significant interaction between gender and age at diagnosis.CONCLUSIONS. The results in the current study were consistent with other published reports that showed an increase in the incidence of brain tumors using SEER data. Although others have observed increasing incidence trends among the elderly, the authors formally tested and found a statistically significant interaction between age at diagnosis and year of diagnosis. (C) 2004 American Cancer Society.