Mixed infection of Trypanosoma cruzi I and II in a Colombian cardiomyopathic patient
Mixed infection of Trypanosoma cruzi I and II in a Colombian cardiomyopathic patient
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DOI：
10.1016/j.humpath.2009.11.005
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发表时间：
2010-04-01
期刊：
影响因子：
3.3
通讯作者：
Isabel Gonzalez, Clara
中科院分区：
文献类型：
--
作者：
Mantilla, Julio C.;Zafra, German A.;Isabel Gonzalez, Clara
克氏锥虫（Trypanosoma cruzi）包括两个主要的谱系：T cruzi I和T cruzi II。查加斯病的临床症状是高度可变的，其地理分布与寄生虫谱系的分布相关。在哥伦比亚和南美洲北方，克氏锥虫I系与恰格曲病性心肌病有关。另外，在南美洲的南锥体国家，克氏锥虫II型占优势，与心肌病和消化系统疾病有关。我们报告的第一次混合感染的T cruzi I和T Cruzi II检测在食道和心脏，分别从流行区在桑坦德，哥伦比亚的心肌病患者。这一发现与克氏锥虫II型与南美锥虫病的临床表现及其在哥伦比亚和南美洲北方国家的发生频率有关，具有流行病学相关性。(C)2010年爱思唯尔公司All rights reserved.
The Trypanosoma cruzi taxon is composed of 2 major lineages, T cruzi I and T cruzi II. The clinical symptoms of Chagas disease are highly variable, and their geographic distribution is correlated with the distribution of the parasite lineages. In Colombia and northern South America, T cruzi I lineage is associated with chagasic cardiomyopathy. Alternatively, in the countries south cone of South America, there is a predominance of T cruzi II, which is associated with cardiomyopathy and digestive diseases. We report for the first time a mixed infection consisting of both T cruzi I and T Cruzi II detected in the esophagus and in the heart, respectively, of a cardiomyopathic patient from an endemic area in Santander, Colombia. This finding has epidemiological relevance related to the association of T cruzi II with the clinical manifestations of Chagas disease and its frequency in Colombia and countries in northern South America. (C) 2010 Elsevier Inc. All rights reserved.