Identification and characterization of cancer stem cells in ovarian yolk sac tumors
Identification and characterization of cancer stem cells in ovarian yolk sac tumors
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DOI：
10.1111/j.1349-7006.2010.01672.x
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发表时间：
2010-10-01
期刊：
影响因子：
5.7
通讯作者：
Kikkawa, Fumitaka
中科院分区：
文献类型：
--
作者：
Suzuki, Shiro;Terauchi, Mikio;Kikkawa, Fumitaka
最近的证据支持癌症干细胞理论，即恶性肿瘤是由被称为癌症干细胞或肿瘤起始细胞的细胞产生的，这些细胞具有自我更新的能力，并负责维持肿瘤。最近在一些实体肿瘤中发现了具有显著启动肿瘤能力的细胞。CD133(PROM1，人显著蛋白-1)已被用作检测各种组织中的干细胞(祖细胞)和肿瘤干细胞(肿瘤起始细胞)的标志物。卵巢卵黄囊肿瘤是一种罕见且高度恶性的肿瘤。本研究旨在评价CD133+细胞在卵巢YST细胞系中的成瘤能力，并检测CD133+细胞的细胞生长和侵袭力等特性。我们的数据表明，卵巢YST是由一小部分表达细胞表面标记CD133的罕见的癌症干细胞维持的。(癌症科学2010)。
Recent evidence supports the cancer stem cell theory, that is, that malignant tumors arise from cells termed cancer stem cells or tumor-initiating cells that have the ability to self-renew and are responsible for maintaining the tumor. Cells with marked tumor-initiating capacity have recently been identified in a number of solid tumors. CD133 (PROM1, human prominin-1) has been used as a marker to detect stem cells (progenitor cells) and cancer stem cells (tumor-initiating cells) in various tissues. Ovarian yolk sac tumors (YSTs) are rare and highly malignant. The present study was designed to evaluate the tumor-forming ability of CD133+ cells in ovarian YST cell lines and to examine the characteristics of CD133+ cells, such as cell growth and invasiveness. Our data suggest ovarian YST to be maintained by a rare fraction of cancer stem-like cells that express the cell surface marker CD133. (Cancer Sci 2010).