Preclinical Alterations in Myocardial Microstructure in People with Metabolic Syndrome
Preclinical Alterations in Myocardial Microstructure in People with Metabolic Syndrome
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DOI：
10.1002/oby.21936
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发表时间：
2017-09-01
期刊：
影响因子：
6.9
通讯作者：
Colucci, Wilson S.
中科院分区：
文献类型：
--
作者：
Ho, Jennifer E.;Rahban, Youssef;Colucci, Wilson S.
目的代谢综合征（MetS）可导致心肌纤维化、舒张功能障碍，最终导致心力衰竭。本研究通过使用一种新的算法来表征超声信号强度变化，评估了 MetS 患者心肌微结构的变化。方法在 254 名没有心血管疾病的参与者中（平均年龄 4211 岁，75% 为女性），其中 162 名患有 MetS，47 名患有肥胖但未患有 MetS，以及 45 名非肥胖对照。进行标准超声心动图检查，并使用一种经过验证的新型计算算法根据超声信号强度和分布来研究心肌微观结构。检查信号强度系数（SIC [左心室微观结构]）。结果与患有 MetS 的人相比，MetS 患者的 SIC 显着更高（P
ObjectiveMetabolic syndrome (MetS) can lead to myocardial fibrosis, diastolic dysfunction, and eventual heart failure. This study evaluated alterations in myocardial microstructure in people with MetS by using a novel algorithm to characterize ultrasonic signal intensity variation.MethodsAmong 254 participants without existing cardiovascular disease (mean age 4211 years, 75% women), there were 162 with MetS, 47 with obesity without MetS, and 45 nonobese controls. Standard echocardiography was performed, and a novel validated computational algorithm was used to investigate myocardial microstructure based on sonographic signal intensity and distribution. The signal intensity coefficient (SIC [left ventricular microstructure]) was examined.ResultsThe SIC was significantly higher in people with MetS compared with people with (P