FREQUENCY AND ROLE OF APO-E PHENOTYPE IN FAMILIAL HYPERCHOLESTEROLEMIA AND NONFAMILIAL HYPERLIPIDEMIA IN THE JAPANESE
FREQUENCY AND ROLE OF APO-E PHENOTYPE IN FAMILIAL HYPERCHOLESTEROLEMIA AND NONFAMILIAL HYPERLIPIDEMIA IN THE JAPANESE
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DOI：
10.1016/0021-9150(90)90041-g
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发表时间：
1990-06-01
期刊：
影响因子：
5.3
通讯作者：
YOSHIDA, S
中科院分区：
文献类型：
--
作者：
KITAHARA, M;SHINOMIYA, M;YOSHIDA, S
研究了65名正常人、426名高脂血症患者和92名家族性高胆固醇血症日本人（FH）的主要载脂蛋白E（apo E）表型的频率，并比较了非FH高脂血症与FH之间的高脂血症特征。载脂蛋白E表型3/3、4/3、3/2、4/4的频率在正常人、非FH高脂血症患者和FH患者中几乎相同。载脂蛋白E7的发生率约占总受试者的0.5%。在IV型和V型高脂血症中，E4/3的发生率高于任何其他高脂血症。III型和V型中E3/2的发生率也较高。在II型非FH高脂血症中，IIb型中E3/2的发生率高于IIa型。E3/2中的VLDL-甘油三酯、VLDL-胆固醇、apo C-II、apo C-III和apo E水平高于E3/3。但在IIa型和IIb型FH中，E3/2的发生率相同，FH中3/2和3/3之间的脂质和载脂蛋白水平相同。这些结果表明等位基因ε 2可能参与VLDL或IDL的保留，但不参与FH。
The frequencies of the major apolipoprotein E(apo E) phenotypes in 65 normal, 426 hyperlipidemics, and 92 familial hypercholesterolemic Japanese subjects (FH) were studied, and features of hyperlipidemia compared between non-FH hyperlipidemia and FH. The frequencies of apo E phenotypes 3/3, 4/3, 3/2, 4/4 were almost the same in normal, non-FH hyperlipidemic, and FH subjects. The incidence of apo E7 was about 0.5% of total subjects. In type IV and V hyperlipidemias, incidence of E4/3 was higher than in any other hyperlipidemia. Incidence of E3/2 was also high in types III and V. In type II non-FH hyperlipidemia, incidence of E3/2 in type IIb was higher than in type IIa. VLDL-triglyceride, VLDL-cholesterol, apo C-II, apo C-III, and apo E levels were higher in E3/2 than in E3/3. But, in type IIa FH and type IIb FH, the incidence of E3/2 was the same, and lipid and apolipoprotein levels between 3/2 and 3/3 in FH were the same. These results indicated that allele .epsilon.2 may be involved in the retention of VLDL or IDL, but not in FH.