Impact of the biological definition of Alzheimer's disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology?
Impact of the biological definition of Alzheimer's disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology?
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DOI：
10.1186/s40035-018-0117-9
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发表时间：
2018
影响因子：
12.6
通讯作者：
Rosa-Neto P
中科院分区：
文献类型：
--
作者：
Gauthier S;Zhang H;Ng KP;Pascoal TA;Rosa-Neto P
NIA-AA研究框架提出了阿尔茨海默病的生物学定义，即无症状的淀粉样沉积患者将被认为在症状之前患有这种疾病。尽管单独的淀粉样蛋白沉积与痴呆症无关，但即使淀粉样蛋白和tau病理的联合关联也不一定需要65岁以上的痴呆症。其他病理因素可能在年龄相关的认知能力下降中起主导或加速作用，包括血管小血管疾病、神经炎症和路易体病理。研究的目的应该是了解所有这些因素之间的相互作用，而不是单独关注它们。希望这将导致一种基于个人生物、基因和认知特征的个性化方法来预防大脑老化。
The NIA-AA research framework proposes a biological definition of Alzheimer’s disease, where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms. Notwithstanding the fact that amyloid deposition in isolation is not associated with dementia, even the combined association of amyloid and tau pathology does not inevitably need to dementia over age 65. Other pathological factors may play a leading or an accelerating role in age-associated cognitive decline, including vascular small vessel disease, neuroinflammation and Lewy Body pathology. Research should aim at understanding the interaction between all these factors, rather than focusing on them individually. Hopefully this will lead to a personalized approach to the prevention of brain aging, based on individual biological, genetic and cognitive profiles.
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DOI：
10.1056/nejmoa1211851
发表时间：
2013-01-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Guerreiro R;Wojtas A;Bras J;Carrasquillo M;Rogaeva E;Majounie E;Cruchaga C;Sassi C;Kauwe JS;Younkin S;Hazrati L;Collinge J;Pocock J;Lashley T;Williams J;Lambert JC;Amouyel P;Goate A;Rademakers R;Morgan K;Powell J;St George-Hyslop P;Singleton A;Hardy J;Alzheimer Genetic Analysis Group
通讯作者：
Alzheimer Genetic Analysis Group
影响因子：
6.3
作者：
Dublin S;Anderson ML;Haneuse SJ;Heckbert SR;Crane PK;Breitner JC;McCormick W;Bowen JD;Teri L;McCurry SM;Larson EB
通讯作者：
Larson EB
DOI：
10.1523/jneurosci.0490-10.2010
发表时间：
2010-05-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clinton LK;Blurton-Jones M;Myczek K;Trojanowski JQ;LaFerla FM
通讯作者：
LaFerla FM
脑淀粉样蛋白血管病及其与阿尔茨海默氏病和其他脑血管神经病理学变化的共同发生。
影响因子：
4.2
作者：
Brenowitz WD;Nelson PT;Besser LM;Heller KB;Kukull WA
通讯作者：
Kukull WA
影响因子：
2.1
作者：
Chao LL;Buckley ST;Kornak J;Schuff N;Madison C;Yaffe K;Miller BL;Kramer JH;Weiner MW
通讯作者：
Weiner MW