BLOOMS SYNDROME .3. ANALYSIS OF CHROMOSOME ABERRATION CHARACTERISTIC OF THIS DISORDER
BLOOMS SYNDROME .3. ANALYSIS OF CHROMOSOME ABERRATION CHARACTERISTIC OF THIS DISORDER
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DOI：
10.1007/bf00290993
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发表时间：
1974-01-01
期刊：
影响因子：
1.6
通讯作者：
BLOOM, D
中科院分区：
文献类型：
--
作者：
GERMAN, J;CRIPPA, LP;BLOOM, D
体细胞染色体之间的染色单体交换是在培养的正常淋巴细胞中偶尔观察到的现象，在布鲁姆氏综合征淋巴细胞中发生的频率大大增加。高度特征性的交换发生在同源染色体上的同源位点，并优先影响某些区域。
Chromatid interchange between somatic chromosomes, a phenomenon occasionally observed in normal lymphocytes in culture, occurs with a greatly increased frequency in Bloom's syndrome lymphocytes. Highly characteristic interchanges occur at apparently homologous sites on homologous chromosomes and affect certain regions preferentially.