Endothelial-Dependent Responses Correlate with Pediatric SOFA Scores During Severe Sepsis and Septic Shock.
Endothelial-Dependent Responses Correlate with Pediatric SOFA Scores During Severe Sepsis and Septic Shock.
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DOI：
10.1007/s12265-021-10202-z
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发表时间：
2022-08
影响因子：
3.4
通讯作者：
Stark, Ryan J.
中科院分区：
文献类型：
--
作者：
Stark, Ryan J.
脓毒症是宿主对感染挑战的过度反应，与血管舒缩张力的显着改变有关。我们假设，严重脓毒症和脓毒性休克期间观察到的内皮功能障碍与儿科序贯器官衰竭评估（pSOFA）评分确定的器官衰竭程度相关。利用激光多普勒灌注监测与离子电渗疗法相结合，我们发现内皮依赖性血管对乙酰胆碱（ACh）刺激的反应性与总 pSOFA 评分显着相关，更具体地说，与心血管（CV） pSOFA 评分显着相关。另外，使用硝普钠 (SNP) 的内皮依赖性血管反应性并未证明与 pSOFA 评分存在显着关系。这些数据表明，内皮介导的血管病变可能是小儿脓毒症发作期间器官功能障碍的关键驱动因素。
Sepsis is an exaggerated host response to an infectious challenge that is associated with significant alterations in vasomotor tone. We hypothesized that the endothelial dysfunction observed during severe sepsis and septic shock would correlate with the degree of organ failure as determined by the pediatric sequential organ failure assessment (pSOFA) score. Utilizing laser Doppler perfusion monitoring coupled with iontophoresis, we found that endothelium-dependent vascular reactivity to acetylcholine (ACh) stimulation significantly correlated with both total pSOFA scores and more specifically, cardiovascular (CV) pSOFA scores. Alternatively, endothelium-independent vascular reactivity using sodium nitroprusside (SNP) did not demonstrate a significant relationship with pSOFA scores. These data suggest that endothelial-mediated vasculopathy may be a key driver of organ dysfunction during episodes of pediatric sepsis.
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DOI：
10.5114/amsad.2019.86754
发表时间：
2019-01-01
期刊：
Archives of medical sciences. Atherosclerotic diseases
影响因子：
--
作者：
Kazune, Sigita;Piebalga, Anda;Vanags, Indulis
通讯作者：
Vanags, Indulis
影响因子：
5.3
作者：
Vaudo, Gaetano;Marchesi, Simona;Mannarino, Elmo
通讯作者：
Mannarino, Elmo
DOI：
10.1097/pcc.0000000000002049
发表时间：
2020-01
期刊：
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
影响因子：
--
作者：
Krispinsky LT;Stark RJ;Parra DA;Luan L;Bichell DP;Pietsch JB;Lamb FS
通讯作者：
Lamb FS
影响因子：
3.1
作者：
Kubli, S;Boëgli, Y;Feihl, F
通讯作者：
Feihl, F