ALTERATIONS OF A ZINC-FINGER ENCODING GENE, BCL-6, IN DIFFUSE LARGE-CELL LYMPHOMA
ALTERATIONS OF A ZINC-FINGER ENCODING GENE, BCL-6, IN DIFFUSE LARGE-CELL LYMPHOMA
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DOI：
10.1126/science.8235596
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发表时间：
1993-10-29
期刊：
影响因子：
56.9
通讯作者：
DALLAFAVERA, R
中科院分区：
文献类型：
--
作者：
YE, BH;LISTA, F;DALLAFAVERA, R
弥漫性大细胞淋巴瘤（DLCL）是最常见且与临床相关的淋巴瘤类型，其分子发病机制尚不清楚。从影响3q27带的染色体易位中克隆出一个基因，这种染色体易位在DLCL中很常见。这个基因，即BCL - 6，编码一种79千道尔顿的蛋白质，该蛋白质与锌指转录因子同源。在33%（39例中的13例）的DLCL样本中，但在其他类型的淋巴恶性肿瘤中没有，BCL - 6基因在其5'非编码序列内被截断，这表明其表达失调。因此，BCL - 6可能是一种特异性参与DLCL发病机制的原癌基因。
The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5' noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.