Dose-response: an International Journal Effects of Low-dose-gamma Rays on the Immune System of Different Animal Models of Disease Effects of Low-dose-gamma Rays on the Immune System of Different Animal Models of Disease
Dose-response: an International Journal Effects of Low-dose-gamma Rays on the Immune System of Different Animal Models of Disease Effects of Low-dose-gamma Rays on the Immune System of Different Animal Models of Disease
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DOI：
10.2203/dose-response.13-042.shimura
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发表时间：
2014-04
期刊：
影响因子：
2.5
通讯作者：
N. Shimura;S. Kojima
中科院分区：
文献类型：
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作者：
N. Shimura;S. Kojima
我们在文献检索的基础上，综述了低剂量电离辐射对几种疾病的有益或有害影响。一些研究小组先前报道了用低剂量γ射线照射的动物疾病模型中自身免疫表现的减弱，而其他人则描述了过敏表现的加剧。基于对文献的详细检查，我们将动物疾病模型分为两组：一组由胶原诱导的关节炎（CIA）、实验性脑脊髓炎（EAE）和系统性红斑狼疮组成，其病理通过低剂量照射减弱，另一组由特应性皮炎、哮喘和桥本甲状腺炎组成，其病理通过低剂量照射加重。在这些研究中检查了相同的生物指标，如细胞因子水平和T细胞亚群。在几乎所有检查的免疫性疾病病例中，低剂量照射降低了干扰素（IFN）-γ（γ）和白细胞介素（IL）-6水平，增加了IL-5水平和CD 4 + CD 25 + Foxp 3 +Treg细胞的百分比。这些生物指标的变化归因于疾病表现的减轻或加重。我们的结论是，由自身抗体引起的自身免疫性疾病被低剂量辐射减弱，而由针对外部抗原的抗体引起的疾病，如特应性皮炎，则加重。
We reviewed the beneficial or harmful effects of low-dose ionizing radiation on several diseases based on a search of the literature. The attenuation of autoimmune manifestations in animal disease models irradiated with low-dose γ-rays was previously reported by several research groups, whereas the exacerbation of allergic manifestations was described by others. Based on a detailed examination of the literature, we divided animal disease models into two groups: one group consisting of collagen-induced arthritis (CIA), experimental encephalomyelitis (EAE), and systemic lupus erythematosus, the pathologies of which were attenuated by low-dose irradiation, and another group consisting of atopic dermatitis, asthma, and Hashimoto's thyroiditis, the pathologies of which were exacerbated by low-dose irradiation. The same biological indicators, such as cytokine levels and T-cell subpopulations, were examined in these studies. Low-dose irradiation reduced interferon (IFN)-gamma (γ) and interleukin (IL)-6 levels and increased IL-5 levels and the percentage of CD4+CD25+Foxp3+Treg cells in almost all immunological disease cases examined. Variations in these biological indicators were attributed to the attenuation or exacerbation of the disease's manifestation. We concluded that autoimmune diseases caused by autoantibodies were attenuated by low-dose irradiation, whereas diseases caused by antibodies against external antigens, such as atopic dermatitis, were exacerbated.