Effects of progesterone on the reinstatement of cocaine-seeking behavior in female rats
Effects of progesterone on the reinstatement of cocaine-seeking behavior in female rats
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DOI：
10.1037/1064-1297.15.5.472
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发表时间：
2007-10-01
影响因子：
2.3
通讯作者：
Carroll, Marilyn E.
中科院分区：
文献类型：
--
作者：
Anker, Justin J.;Larson, Erin B.;Carroll, Marilyn E.
苯甲酸雌二醇（Estradiol benzoate， EB）可促进去卵巢（OVX）大鼠可卡因寻求行为的获得和恢复。相比之下，黄体酮(P)减少可卡因自我给药的获得，但P对恢复药物寻求的影响尚不清楚。本研究的目的是比较EB和P对雌性大鼠可卡因寻求行为恢复的影响。大鼠接受OVX或假手术（SH），并训练杠杆按压静脉注射可卡因（0.4 mg/kg），在固定比例1,20秒的暂停计划下，每天2小时。反应稳定14天后，用生理盐水代替可卡因，21天的消退期开始。灭绝后，将大鼠分为5个治疗组（OVX + EB、OVX + EB + P、OVX +载药[VEH]、SH + P、SH + VEH）， VEH、EB、EB + P分别于每次治疗前30 min给药，连续5 d。激素治疗3天后，大鼠注射生理盐水或可卡因（10 mg/kg），评估杠杆反应的恢复情况。OVX+ EB组的恢复反应高于OVX+ EB + P、SH + P和OVX+VEH组，后者的可卡因启动反应水平较低。SH + VEH组和OVX + EB组表现出相似的高水平的可卡因诱导恢复。P治疗后对可卡因诱导恢复的抑制表明，P在预防女性可卡因使用者再次自我给药方面发挥了作用。
Estradiol benzoate (EB) facilitates the acquisition and reinstatement of cocaine-seeking behavior when administered to ovariectomized (OVX) rats. In contrast, progesterone (P) decreases acquisition of cocaine self-administration, but the effects of P on the reinstatement of drug seeking are not known. The purpose of the present study was to compare the effects of EB and P on the reinstatement of cocaine-seeking behavior in female rats. Rats received either OVX or sham surgery (SH) and were trained to lever press for intravenous cocaine infusions (0.4 mg/kg) under a fixed ratio 1, 20-s time-out schedule during daily 2-hr sessions. After 14 days of stable responding, saline replaced cocaine, and a 21-day extinction period began. After extinction, rats were separated into 5 treatment groups (OVX + EB, OVX + EB + P, OVX + vehicle [VEH], SH + P, or SH + VEH), and VEH, EB, or EB + P was administered 30 min prior to each session for 5 days. After 3 days of hormone treatment, rats received a saline or cocaine (10 mg/kg) injection, and reinstatement of lever responding was assessed. Reinstatement responding in the OVX + EB group was greater relative to the OVX + EB + P, SH + P, and OVX+VEH groups, which had low levels of cocaine-primed responding. The SH + VEH and OVX + EB groups displayed similar high levels of cocaine-elicited reinstatement. The suppression of cocaine-induced reinstatement following P treatment suggests a role for P in the prevention of relapse to cocaine self-administration in female cocaine users.