Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol.
Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol.
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DOI：
10.3233/jad-2011-0004
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Frisoni GB
中科院分区：
文献类型：
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作者：
Boccardi M;Ganzola R;Bocchetta M;Pievani M;Redolfi A;Bartzokis G;Camicioli R;Csernansky JG;de Leon MJ;deToledo-Morrell L;Killiany RJ;Lehéricy S;Pantel J;Pruessner JC;Soininen H;Watson C;Duchesne S;Jack CR Jr;Frisoni GB
磁共振成像（MR）的手动分割是评估阿尔茨海默病（AD）海马萎缩的金标准。尽管如此，不同的分割协议提供高达2.5倍的体积差异。在这里，我们调查了AD文献中最常用的分割协议，作为国际协调的初步步骤。所述解剖界标从12个已发表的海马手动分割协议中识别出（最前和最后切片、上级、下级、内侧和外侧边界（[缩写]第一作者，出版年份：[B] Bartzokis，1998; [C] Convit，1997; [dTM] deToledo-Morrell，2004; [H] Haller，1997; [J] Jack，1994;[K] Killiany，1993; [L] Lehericy，1994; [M] Malykhin，2007; [Pa] Pantel，2000; [Pr] Pruessner，2000; [S] Soininen，1994; [W]沃森，1992）。从1.5T MR ADNI数据库中选取一名健康对照和一名AD患者的大脑半球，由一名评分员根据每种方案进行分割。通过单独的互动网络会议，与协议的主要作者一起检查协议解释和付诸实践的准确性。然后提取语义协调的标志和差异，关于：（a）最后切片，协议[B]是最严格的，并且[H，M，Pa，Pr，S]是最包容的;（B）包括[C，dTM，J，L，M，Pr，W]或排除[B，H，K，Pa，S]肺泡/伞;（c）与海马旁回分离，[C]限制性最强，[B、dTM、H、J、Pa、S]包容性最强。在最前切片的定义方面没有实质性差异。这项调查将使我们能够将协议之间的差异操作化为跟踪单元，测量其对手动海马分割的可重复性和诊断准确性的影响，并最终制定一个统一的协议。
Manual segmentation from magnetic resonance imaging (MR) is the gold standard for evaluating hippocampal atrophy in Alzheimer’s disease (AD). Nonetheless, different segmentation protocols provide up to 2.5-fold volume differences. Here we surveyed the most frequently used segmentation protocols in the AD literature as a preliminary step for international harmonization. The anatomical landmarks (anteriormost and posteriormost slices, superior, inferior, medial, and lateral borders) were identified from 12 published protocols for hippocampal manual segmentation ([Abbreviation] first author, publication year: [B] Bartzokis, 1998; [C] Convit, 1997; [dTM] deToledo-Morrell, 2004; [H] Haller, 1997; [J] Jack, 1994; [K] Killiany, 1993; [L] Lehericy, 1994; [M] Malykhin, 2007; [Pa] Pantel, 2000; [Pr] Pruessner, 2000; [S] Soininen, 1994; [W] Watson, 1992). The hippocampi of one healthy control and one AD patient taken from the 1.5T MR ADNI database were segmented by a single rater according to each protocol. The accuracy of the protocols’ interpretation and translation into practice was checked with lead authors of protocols through individual interactive web conferences. Semantically harmonized landmarks and differences were then extracted, regarding: (a) the posteriormost slice, protocol [B] being the most restrictive, and [H, M, Pa, Pr, S] the most inclusive; (b) inclusion [C, dTM, J, L, M, Pr, W] or exclusion [B, H, K, Pa, S] of alveus/fimbria; (c) separation from the parahippocampal gyrus, [C] being the most restrictive, [B, dTM, H, J, Pa, S] the most inclusive. There were no substantial differences in the definition of the anteriormost slice. This survey will allow us to operationalize differences among protocols into tracing units, measure their impact on the repeatability and diagnostic accuracy of manual hippocampal segmentation, and finally develop a harmonized protocol.