Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus
Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus
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DOI：
10.1016/s0168-8227(01)00373-4
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发表时间：
2002-06-01
影响因子：
5.1
通讯作者：
Adachi, Y
中科院分区：
文献类型：
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作者：
Furuta, M;Yano, Y;Adachi, Y
曲格列酮已被证明可以改善2型糖尿病患者和动物模型的外周胰岛素抵抗。我们研究了曲格列酮对肥胖2型糖尿病动物模型大冢长埃文斯德岛脂肪（OLETF）大鼠肌肉和脂肪组织中葡萄糖转运蛋白4（GLUT 4）表达的影响。此外，还评价了曲格列酮对脂肪细胞中GLUT 4易位和葡萄糖转运活性的影响。从35周龄的雄性曲格列酮给药和未给药OLETF大鼠中分离肌肉和脂肪组织，剂量为150 mg/kg/天，持续14天。在骨骼肌中，OLETF和对照组大鼠之间GLUT 4的蛋白和mRNA水平没有显著差异，并且它们不受曲格列酮的影响。另一方面，OLETF大鼠脂肪组织中GLUT 4蛋白和mRNA水平显著降低（P
Troglitazone has been shown to improve peripheral insulin resistance in type 2 diabetic patients and animal models. We examined the effect of troglitazone on the expression of glucose transporter 4 (GLUT4) in muscle and adipose tissue from Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model of obese type 2 diabetes mellitus. In addition, the effects of troglitazone on GLUT4 translocation and on glucose transport activity in adipocytes were also evaluated. Muscle and adipose tissues were isolated from 35-week-old male troglitazone-treated and untreated OLETF rats at a dose of 150 mg/kg per day for 14 days. In skeletal muscle, the protein and mRNA levels of GLUT4 were not significantly different between OLETF and control rats and they were not affected by troglitazone. On the other hand, GLUT4 protein and mRNA levels in adipose tissue from OLETF rats were significantly decreased (P