Brain-specific-homeobox is required for the specification of neuronal types in the Drosophila optic lobe
Brain-specific-homeobox is required for the specification of neuronal types in the Drosophila optic lobe
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DOI：
10.1016/j.ydbio.2013.02.012
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发表时间：
2013-05-01
影响因子：
2.7
通讯作者：
Sato, Makoto
中科院分区：
文献类型：
--
作者：
Hasegawa, Eri;Kaido, Masako;Sato, Makoto
果蝇视叶包含多种神经元，这些神经元形成类似于哺乳动物大脑的层状和柱状结构。果蝇视叶可能为研究大脑发育的各种过程提供一个极好的模型。然而，人们对视叶中神经元特化如何受到调控以形成复杂结构知之甚少。在此我们表明，在板层和髓质神经节中表达的脑特异性同源框（Bsh）蛋白参与神经元特性的确定。Bsh在L4和L5板层神经元以及Mi1髓质神经元中表达。对功能缺失和功能获得克隆的分析表明，Bsh是髓质中Mi1特化以及板层中L4特化所必需的，并且在很大程度上是充分的。此外，Bsh至少是L5特化所必需的。在没有Bsh的情况下，L5会转变成神经胶质细胞。（C）2013爱思唯尔公司。保留所有权利。
The Drosophila optic lobe comprises a wide variety of neurons forming laminar and columnar structures similar to the mammalian brain. The Drosophila optic lobe may provide an excellent model to investigate various processes of brain development. However, it is poorly understood how neuronal specification is regulated in the optic lobe to form a complicated structure. Here we show that the Brain-specific-homeobox (Bsh) protein, which is expressed in the lamina and medulla ganglia, is involved in specifying neuronal identity. Bsh is expressed in L4 and L5 lamina neurons and in Mi1 medulla neurons. Analyses of loss-of-function and gain-of-function clones suggest that Bsh is required and largely sufficient for Mi1 specification in the medulla and L4 specification in the lamina. Additionally, Bsh is at least required for L5 specification. In the absence of Bsh, L5 is transformed into glial cells. (C) 2013 Elsevier Inc. All rights reserved.