The NMDA antagonist MK-801 affects nonspatial learning in preweanling rats
The NMDA antagonist MK-801 affects nonspatial learning in preweanling rats
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DOI：
10.1037/0735-7044.110.2.300
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发表时间：
1996-04-01
影响因子：
1.9
通讯作者：
Amsel, A
中科院分区：
文献类型：
--
作者：
Highfield, DA;Nixon, K;Amsel, A
兴奋性氨基酸受体的 N-甲基-D-天冬氨酸 (NMDA) 亚型与多种学习和记忆以及长时程增强 (LTP) 相关。一种假定的学习和记忆细胞机制。本实验检查了断奶前大鼠腹腔注射 0.05 mg/kg MK-801（一种选择性 NMDA 拮抗剂）后 NMDA 受体对模式化单交替 (PSA) 学习的作用。 MK-801 在 60 秒和 30 秒试验间隔 (ITI) 时显着抑制 PSA，并在 8 秒 ITI 时减弱但不阻断学习。这些结果与对 PSA 的影响进行了比较，PSA 是一种非空间的、基于记忆的学习形式，是在产后早期接触酒精、婴儿海马病变和婴儿接触 X 射线后观察到的，并且强烈地补充了这些早期证明的海马在学习和记忆中的作用，这种作用显然与非空间和非认知图相关。
The N-methyl-D-aspartate (NMDA) subtype of the excitatory amino acid receptor has been implicated in several kinds of learning and memory, as well as in long-term potentiation (LTP). a putative cellular mechanism for learning and memory. This experiment examined the role of the NMDA receptor on patterned single-alternation (PSA) learning in preweanling rats following intraperitoneal injections of 0.05 mg/kg MK-801, a selective NMDA antagonist. MK-801 significantly inhibited PSA at both 60-s and 30-s intertrial intervals (ITIs), and attenuated, but did not block, learning at 8-s ITI. These results are compared with effects on PSA, a form on nonspatial, memory-based learning, observed after early postnatal exposure to alcohol, infant hippocampal lesions, and infant exposure to X-irradiation, and the add strongly to these earlier demonstrations of the role of the hippocampus in learning and memory that is clearly nonspatial and non-cognitive-map-related.