Emerging Concepts of Vascular Cell Clonal Expansion in Atherosclerosis.
Emerging Concepts of Vascular Cell Clonal Expansion in Atherosclerosis.
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DOI：
10.1161/atvbaha.121.316093
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Fisher EA
中科院分区：
文献类型：
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作者：
Misra A;Rehan R;Lin A;Patel S;Fisher EA
克隆扩张是一个可以驱动人类疾病发病机制的过程，动脉粥样硬化就是一个突出的例子。尽管对动脉粥样硬化病因的了解取得了进展，但血管细胞的克隆性研究仍处于早期阶段。最近，几项范式转变的临床前研究已经确定了血管系统中祖细胞的克隆扩张，以响应动脉粥样硬化。本综述概述了动脉粥样硬化进展中的细胞克隆性，特别关注平滑肌细胞和巨噬细胞。我们讨论了最新研究的主要发现，这些发现深入了解了血管细胞的克隆扩张导致疾病病理学的机制。对这些机制的进一步探讨将为动脉粥样硬化及其相关心血管疾病的理解和治疗的未来进展提供创新方向。
Clonal expansion is a process that can drive pathogenesis in human diseases, with atherosclerosis being a prominent example. Despite advances in understanding the etiology of atherosclerosis, clonality studies of vascular cells remain in an early stage. Recently, several paradigm-shifting pre-clinical studies have identified clonal expansion of progenitor cells in the vasculature in response to atherosclerosis. This review provides an overview of cell clonality in atherosclerotic progression, focusing particularly on smooth muscle cells and macrophages. We discuss key findings from the latest research that give insight into the mechanisms by which clonal expansion of vascular cells contributes to disease pathology. The further probing of these mechanisms will provide innovative directions for future progress in the understanding and therapy of atherosclerosis and its associated cardiovascular diseases.