Spatial Patterns of Persistent Neural Activity Vary with the Behavioral Context of Short-Term Memory
Spatial Patterns of Persistent Neural Activity Vary with the Behavioral Context of Short-Term Memory
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DOI：
10.1016/j.neuron.2015.01.006
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发表时间：
2015-02-18
期刊：
影响因子：
16.2
通讯作者：
Aksay, Emre R. F.
中科院分区：
文献类型：
--
作者：
Daie, Kayvon;Goldman, Mark S.;Aksay, Emre R. F.
短期记忆可以由不同的输入唤起，并在不同的行为背景下控制不同的目标。为了解决背景相关记忆功能背后的电路机制，我们通过光学成像确定了在两种行为设置下，记忆是如何在全网络水平上编码的。在眼跳或视动刺激后，持续的神经活动维持对所需眼位的记忆，在整个眼动积分器中被成像。虽然眼睛的位置由网络活动的幅度编码，但放电的空间模式与环境有关：通常位于尾部的细胞在扫视输入后最持久，而位于头端的细胞在视动输入后最持久。为了解释这些数据，我们通过计算确定了四种独立的网络活动模式，并发现这些模式是通过扫视和视动输入进行差异访问的。这些结果表明，一个电路如何分别在其持续放电的幅度和空间模式中同时编码记忆值和行为背景。
A short-term memory can be evoked by different inputs and control separate targets in different behavioral contexts. To address the circuit mechanisms underlying context-dependent memory function, we determined through optical imaging how memory is encoded at the whole-network level in two behavioral settings. Persistent neural activity maintaining a memory of desired eye position was imaged throughout the oculomotor integrator after saccadic or optokinetic stimulation. While eye position was encoded by the amplitude of network activity, the spatial patterns of firing were context dependent: cells located caudally generally were most persistent following saccadic input, whereas cells located rostrally were most persistent following optokinetic input. To explain these data, we computationally identified four independent modes of network activity and found these were differentially accessed by saccadic and optokinetic inputs. These results show how a circuit can simultaneously encode memory value and behavioral context, respectively, in its amplitude and spatial pattern of persistent firing.