A framework to assess the terrestrial risk of antibiotic resistance from antibiotics in slurry or manure amended soils
A framework to assess the terrestrial risk of antibiotic resistance from antibiotics in slurry or manure amended soils
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DOI：
10.1039/d2va00306f
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发表时间：
2023-05-09
期刊：
影响因子：
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通讯作者：
Carter，Laura J.
中科院分区：
文献类型：
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作者：
Elder，Felicity C. T.;O'Neill，Alex J.;Carter，Laura J.
抗生素耐药性（ABR）或无声大流行是一个重大的全球健康和经济问题，威胁着现代医疗保健和粮食生产。人们越来越担心环境中抗生素的存在可能会导致抗生素耐药性的出现和传播。目前环境监管指南未能解决 ABR 风险，尽管水生环境中正在开展解决这一问题的工作，但陆地系统却在一定程度上被忽视了——这可能部分是由于重点关注废水处理厂废水作为环境中抗生素的主要来源。在农业领域，越来越多的人不再使用化学肥料，而是使用有机土壤改良剂（例如泥浆、粪肥或污泥）来改善土壤健康。然而，这些有机土壤改良剂已被证明含有抗生素和其他药物以及抗生素抗性细菌，通过 ABR 的增殖和传播对环境、牲畜和人类构成潜在风险。因此，制定与 ABR 和有机土壤改良剂使用相关的风险框架非常重要。利用当前关于抗生素在土壤中的命运和数学模型的知识，本手稿提出了一个新颖的框架，用于通过使用农家肥作为肥料来评估抗生素耐药性的陆地风险。
Antibiotic resistance (ABR) or the silent pandemic is a major global health and economic issue, threatening both modern healthcare and food production. There is increasing concern that the presence of antibiotics in the environment may select for the emergence and spread of antibiotic resistance. Currently environmental regulatory guidelines fail to address ABR risks, and while there is ongoing work to address this within aquatic environments, terrestrial systems have been somewhat overlooked – perhaps in part due to a focus on wastewater treatment plant effluent as the main source of antibiotics within the environment. Within agriculture there is an increasing push to move away from chemical-based fertilisers and towards the use of organic soil amendments such as slurry, manure or sludge, to improve soil health. However, these organic soil amendments have been shown to contain antibiotics and other pharmaceuticals alongside antibiotic resistant bacteria, posing a potential risk to the environment, livestock and humans through the proliferation and spread of ABR. It is therefore important that a risk framework is developed in relation to ABR and organic soil amendment use. Using current knowledge on the fate of antibiotics within soil and mathematical models, this manuscript presents a novel framework for assessing the terrestrial risk of antibiotic resistance through the use of farmyard manure as fertiliser.