The Everted Rat Intestine Used as a Model System to Demonstrate Regulation of Sodium Absorption Following Hemorrhage
The Everted Rat Intestine Used as a Model System to Demonstrate Regulation of Sodium Absorption Following Hemorrhage
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外翻的大鼠肠道用作模型系统来演示出血后钠吸收的调节
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
R. C. Ingraham
中科院分区：
文献类型：
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作者：
I. Martinson;R. C. Ingraham
总结和结论 与对照值相比，在失血后期间从狗获得的血浆增加了外翻的大鼠节段中钠的吸收。给狗输注血管紧张素（1μg/分钟）60分钟后获得的血浆也导致外翻肠道制剂中钠吸收量显着高于对照值。直接将血管紧张素添加到外翻的大鼠肠道的浆膜溶液中不会增加钠的吸收。与 20% 出血后发现的浓度相当的加压素对钠吸收没有影响。总之，实验证据支持这样的假设：血容量收缩后，血浆成分发生变化，这确实显着影响外翻大鼠节段中钠的吸收。因此，肠道中存在的这种机制应该补充肾脏在体内钠稳态调节中的作用。
Summary and Conclusion Plasma obtained from dogs during the posthemorrhage period increased the absorption of sodium in the everted rat segment over control values. The plasma obtained after dogs were infused for 60 min with angiotensin (1 μg/min) also resulted in a significant increase in sodium absorption in the everted gut preparation over the control values. Angiotensin added directly to the serosal solution in the everted rat gut did not increase sodium absorption. Vasopressin at a concentration equivalent to that found following a 20% hemorrhage had no effect on sodium absorption. In conclusion, the experimental evidence supports the hypothesis that following contraction of the blood volume there is a change in the composition of the plasma that does significantly affect the absorption of sodium in an everted rat segment. This mechanism present in the intestine, then, should complement the role of the kidney in the homeostatic regulation of total body sodium.