SPECIFICITY OF T-CELL CLONES ILLUSTRATES ALTERED SELF HYPOTHESIS
SPECIFICITY OF T-CELL CLONES ILLUSTRATES ALTERED SELF HYPOTHESIS
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DOI：
10.1038/294460a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
BEVAN, MJ
中科院分区：
文献类型：
--
作者：
HUNIG, T;BEVAN, MJ
细胞毒性 T 淋巴细胞 (CTL) 在自身主要组织相容性抗原的背景下识别外来抗原。在小鼠中，这种现象称为 H-2 限制，因为 H-2 是主要的组织相容性复合体。人们提出了两种理论来解释 CTL 杀死特异性靶细胞的双重要求：(1) 双受体假说提出 T 细胞具有抗自身 H–2 受体和独特的抗外来（抗 X）受体 1,2； (2) 改变的自我假设提出，T 细胞识别由自身 H-2 分子和靶细胞膜中的 X 物理相互作用产生的复杂抗原或相互作用抗原3,4。在这里，我们报告了识别 H–2k-plus-X 并与 H–2d-plus-Y 交叉反应的 CTL 克隆的分离。因为克隆识别两对抗原而不是任何组合，例如 H-2k-plus-Y，所以它们非常强烈地支持改变自我识别的原理，即仅识别 H-2 和外来抗原的复合物，而不是单独识别任何一个成分。
Cytotoxic T lymphocytes (CTLs) recognize foreign antigens in the context of self major histocompatibility antigens. In the mouse this phenomenon is called H–2 restriction as H–2 is the major histocompatibility complex. Two theories have been proposed to explain the dual requirement for CTLs to kill specifically target cells: (1) the two-receptor hypothesis proposes that T cells have an anti-self H–2 receptor and a distinct anti-foreign (anti-X) receptor1,2; (2) the altered self hypothesis proposes that T cells recognize complex antigens or interaction antigens created by the physical interaction of self H–2 molecules and X in the target cell membrane3,4. Here we report the isolation of CTL clones which recognize H–2k-plus-X and cross-react with H–2d-plus-Y. Because the clones recognize two pairs of antigens and not any combination, for example, H–2k-plus-Y, they support very strongly the principle of altered self recognition, that is, that only the complex of H–2 and foreign antigen is recognized and not either component independently.