Comparative phytochemical and anti‑bacterial studies of two indigenous medicinal plants Curcuma caesia Roxb. and Curcuma aeruginosa Roxb
Comparative phytochemical and anti‑bacterial studies of two indigenous medicinal plants Curcuma caesia Roxb. and Curcuma aeruginosa Roxb
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两种本土药用植物姜黄和铜绿姜黄的植物化学和抗菌比较研究。
DOI：
10.4103/0973-8258.126828
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
T. D. Thomas
中科院分区：
文献类型：
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作者：
Sweetymol Jose;T. D. Thomas
背景：传统药用植物可以作为新的可靠的、可生物降解的、可再生的药物的良好来源，并可以直接或间接地利用其抗菌活性。目的：评价姜科药用植物姜黄和郁金的植物化学成分和抑菌性能。材料和方法：对用甲醇提取的根茎提取物进行活性成分的评价。对不同的植物成分进行了定性分析。用不同浓度的正己烷、氯仿、乙酸乙酯、丙酮、甲醇和水系列提取物(1.25、2.5、5.0 mg/ml)对革兰氏阳性菌(金黄色葡萄球菌、溶血性链球菌和蜡样芽孢杆菌)和革兰氏阴性菌(伤寒沙门氏菌、产气肠杆菌、霍乱弧菌、铜绿假单胞菌和粘质沙雷氏菌)进行了抑菌试验。严格按照国家临床实验室标准委员会(NCCL)标准，采用纸片扩散法进行纸片药敏试验。统计分析：所有结果值均以两次独立实验±标准差表示。结果：对这两种植物进行植物化学筛选，证实其含有多种生物活性物质，从而验证了其在中草药中的应用。抗菌研究表明，对所有受试菌均有不同程度的抑制作用。革兰氏阳性菌中，铜绿假单胞菌丙酮提取物对金黄色葡萄球菌活性最高，铜绿假单胞菌正己烷提取物对蜡样芽孢杆菌活性最高。在革兰氏阴性菌中，鱼腥草的氯仿提取物对粘质沙门氏菌的抑制作用最强，而铜绿假单胞菌的甲醇提取物对伤寒沙门氏菌的抑制作用较强。结论：本研究结果表明，根茎提取物具有良好的抗菌潜力，通过合理的评价程序，可用于多种细菌感染性疾病的治疗。本研究验证了这些植物在传统医学中的使用，并建议为治疗需要制造新的药物。关键词：抗菌活性、铜姜黄、姜黄、药用植物、植物提取物
Background: Traditional medicinal plants could serve as a good supply of new dependable, biodegradable, renewable drugs and can be utilised for its anti‑bacterial activity directly or indirectly. Aims: To evaluate the phytochemical and anti‑bacterial properties of two morphologically similar indigenous medicinal plants Curcuma caesia and Curcuma aeruginosa belonging to the family Zingiberaceae. Materials and Methods: Evaluation of rhizome extracts using methanol was performed for the presence of active principles. Qualitative analysis was carried out for diverse phytoconstituents. Different concentrations (1.25, 2.5, 5.0 mg/ml) of hexane, chloroform, ethyl acetate, acetone, methanol and water serial extracts from the rhizome of C. caesia and C. aeruginosa were tested against Gram positive (Staphylococcus aureus, Streptococcus haemolyticus and Bacillus cereus) and Gram negative (Salmonella typhi, Enterobacter aerogens, Vibrio cholerae, Pseudomonas aeruginosa and Serratia marcescens) bacteria. National Committee for Clinical Laboratory Standard (NCCL) standards were strictly followed to perform anti‑bacterial disc susceptibility test using disc diffusion method. Statistical Analysis: All the values of the results were expressed as means of two independent experiments ± standard deviation. Results: Phytochemical screening of these two plants confirmed the presence of various bioactive substances and thus validating its use in herbal remedies. Anti‑bacterial studies showed varying degree of inhibitory action against all the tested bacteria. Among the Gram positive bacteria, acetone extract of C. caesia showed maximum activity against S. aureus and hexane extract of C. aeruginosa exhibited maximum activity against B. cereus. In Gram negative bacteria, chloroform extract of C. caesia showed maximum inhibitory action against S. marcescens, whereas the methanol extract of C. aeruginosa showed higher inhibitory action against S. typhi. Conclusions: The findings about present study suggest that the rhizome extract possess excellent anti‑bacterial potential that can be used for therapeutic purposes for many bacterial infectious diseases with proper evaluation procedures. The present study validated the use of these plants in traditional medicine and recommends for making new pharmaceuticals for therapeutic needs. Key words: Anti‑bacterial activity, Curcuma aeruginosa, Curcuma caesia, medicinal plants, plant extracts
食物还是药物？-姜黄属草药
DOI：
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发表时间：
2006
期刊：
影响因子：
--
作者：
Komatsu;K
通讯作者：
K