Bivalent cationic ions doped bioactive glasses: the influence of magnesium, zinc, strontium and copper on the physical and biological properties
Bivalent cationic ions doped bioactive glasses: the influence of magnesium, zinc, strontium and copper on the physical and biological properties
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DOI：
10.1007/s10853-017-1010-0
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发表时间：
2017-08-01
影响因子：
4.5
通讯作者：
Cacciotti, Ilaria
中科院分区：
文献类型：
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作者：
Cacciotti, Ilaria
生物活性玻璃和微晶玻璃材料在骨科、牙科和颌面外科以及组织工程领域被广泛用作骨强化和修复的替代品。事实上，这些材料具有生物活性、生物相容性、机械稳定性、可生物降解性和有利于骨整合，能够促进其表面的骨组织形成，并在植入人体后与周围的活组织结合。研究表明，生物玻璃离子溶解产物(如硅、钙、磷和钠)能够诱导和刺激成骨细胞分化和骨形成相关基因的表达，在体外和体内都能刺激血管生成，并具有可能的抗菌和抗炎作用。因此，有可能适当地调整BGS的性质，制定它们的化学组成，并添加具有特定功能和生物作用的选定离子。从这个角度来看，汉奇提出了新一代基因设计的玻璃，基于它们激活参与原位组织再生的特定基因的能力，通过在硅酸盐和磷酸盐玻璃中掺杂几种活性离子，特别是具有治疗作用的金属离子。在这一框架下，本综述的目的是概述生物玻璃结构中引入的某些阳离子取代物(即镁、锌、锶和铜)对这些材料的物理和生物性能的影响，因为理解最常用的金属离子的影响对于解决更有前景和更有性能的玻璃的配方至关重要。
Bioactive glass and glass ceramic materials are widely used as substitutes for bone augmentation and restoration, in orthopaedic, dental and maxillofacial surgery and in the tissue engineering field. Indeed, these materials are bioactive, biocompatible, mechanically stable, biodegradable and favour osteointegration, being able to promote bone tissue formation at their surface and to bond to surrounding living tissues when implanted in the human body. It has been demonstrated that bioglass (BG) ionic dissolution products (e.g. Si, Ca, P and Na) are able to induce and stimulate the expressions of genes related to the osteoblastic differentiation and bone formation, to stimulate angiogenesis in vitro and in vivo, as well as to play possible antibacterial and anti-inflammatory actions. Thus, it is possible to tailor BGs properties properly formulating their chemical composition and adding selected ions with specific functional and biological role. In this perspective, Hench proposed a new generation of genetically designed glasses, on the basis of their ability to activate specific genes involved in in situ tissue regeneration, by doping silicate and phosphate glasses with several active ions, particularly metallic ions with therapeutic effects. In this framework, the present review is aimed to provide an overview about the effect of selected cationic substitutions (i.e. magnesium, zinc, strontium and copper), incorporated within the bioglasses structure, on the physical and biological properties of these materials, since the comprehension of the influence of the most employed metallic ions has to be considered pivotal to address the formulation of more promising and performing glasses.