In vivo measurement of plaque burden in a mouse model of Alzheimer's disease
In vivo measurement of plaque burden in a mouse model of Alzheimer's disease
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DOI：
10.1002/jmri.20751
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发表时间：
2006-11-01
影响因子：
4.4
通讯作者：
Reddy, Ravinder
中科院分区：
文献类型：
--
作者：
Borthakur, Arijitt;Gur, Tamar;Reddy, Ravinder
目的：建立一种直接显示APP/PS1转基因(TG)小鼠脑内淀粉样β蛋白(A-β)斑块的MRI方法，并显示T-1p松弛速率随阿尔茨海默病(AD)相关病理改变而递增。材料和方法：我们在体内获得了高表达人类淀粉样前体蛋白的AD(APP/PS1)小鼠模型的MR图像，并通过定量弛豫图测量了T-1p。结果：与年龄匹配的对照组相比，12和18个月龄的小鼠大脑皮质和海马区的T-1p显著降低。结论：T-1p松弛测量法可能是一种敏感的无创性检测API/PS1小鼠AD相关病理改变的方法。
Purpose: To demonstrate an MRI method for directly visualizing amyloid-beta (A beta) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T-1p relaxation rate increases progressively with Alzheimer's disease (AD)-related pathology in the tg mouse brain.Materials and Methods: We obtained in vivo MR images of a mouse model of AD (APP/PS1) that overexpres ses human amyloid precursor protein, and measured T-1p via quantitative relaxometric maps.Results: A significant decrease in T-1p was observed in the cortex and hippocampus of 12- and 18-month-old animals compared to their age-matched controls. There was also a correlation between changes in T-1p and the age of the ahimals.Conclusion: T-1p relaxometry may be a sensitive method for noninvasively determining AD-related pathology in API/PS1 mice.