Targeting innate immunity for neurodegenerative disorders of the central nervous system.
Targeting innate immunity for neurodegenerative disorders of the central nervous system.
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DOI：
10.1111/jnc.13667
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发表时间：
2016-09
影响因子：
4.7
通讯作者：
Van Eldik LJ
中科院分区：
文献类型：
--
作者：
Andreasson KI;Bachstetter AD;Colonna M;Ginhoux F;Holmes C;Lamb B;Landreth G;Lee DC;Low D;Lynch MA;Monsonego A;O'Banion MK;Pekny M;Puschmann T;Russek-Blum N;Sandusky LA;Selenica ML;Takata K;Teeling J;Town T;Van Eldik LJ
神经炎症与许多神经退行性疾病密切相关，因此天然免疫激活的关键信号步骤是有希望的治疗靶点。这一小型综述系列源于2015年5月7日至9日在德国波恩举行的第四届Venusberg神经炎症会议，介绍了急性脑损伤和慢性神经退行性疾病(如创伤性脑损伤和阿尔茨海默病)中天然免疫的最新进展，星形胶质细胞和小胶质细胞的作用，以及可能有助于阐明神经炎症机制和建立临床相关性的技术发展。在这份会议报告中，简要概述了小胶质细胞的生理和病理形态，随后简要介绍了PGE2受体，对精氨酸代谢的作用以及各种临床环境中神经炎症的进一步相关方面的见解，最后介绍了使用小胶质细胞和星形胶质细胞培养时的技术挑战和解决方案。小胶质细胞个体发育和诱导的多能干细胞来源的小胶质细胞，TREM2信号的进展，以及阿尔茨海默病中的细胞因子悖论是对这一系列研究的进一步贡献。神经炎症与许多神经退行性疾病密切相关，因此天然免疫激活的关键信号步骤是有希望的治疗靶点。这一小型综述系列源于2015年5月7日至9日在德国波恩举行的第四届Venusberg神经炎症会议，介绍了急性脑损伤和慢性神经退行性疾病(如创伤性脑损伤和阿尔茨海默病)的先天免疫、星形胶质细胞和小胶质细胞的作用以及可能有助于阐明神经炎症机制和建立临床相关性的技术发展的最新情况。在这份会议报告中，简要概述了小胶质细胞的生理和病理形态，随后简要介绍了PGE2受体，对精氨酸代谢的作用以及各种临床环境中神经炎症的进一步相关方面的见解，最后介绍了使用小胶质细胞培养时的技术挑战和解决方案。小胶质细胞个体发育和诱导的多能干细胞来源的小胶质细胞，TREM2信号转导的进展，以及阿尔茨海默病中的细胞因子悖论是本文的进一步贡献。
Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer’s disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview of physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, concluded by a presentation of technical challenges and solutions when working with microglia and astrocyte cultures. Microglial ontogeny and induced pluripotent stem cell derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer’s disease are further contributions to this series. Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders such as traumatic brain injury and Alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview on physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, concluded by a presentation of technical challenges and solutions when working with microglia cultures. Microglial ontogeny and induced pluripotent stem cell derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer’s disease are further contributions to this article.