Fatty liver, abdominal adipose tissue and atherosclerotic calcification in African Americans: The Jackson Heart Study
Fatty liver, abdominal adipose tissue and atherosclerotic calcification in African Americans: The Jackson Heart Study
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DOI：
10.1016/j.atherosclerosis.2012.07.042
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发表时间：
2012-10-01
期刊：
影响因子：
5.3
通讯作者：
Fox, Caroline S.
中科院分区：
文献类型：
--
作者：
Liu, Jiankang;Musani, Solomon K.;Fox, Caroline S.
目的：脂肪肝和腹部内脏脂肪（VAT）均与心脏代谢危险因素相关。脂肪肝和 VAT 是否与冠状动脉 (CAC) 或腹主动脉 (AAC) 钙化共同相关尚不清楚。方法：杰克逊心脏研究 (JHS) 参与者（n = 2884，平均年龄 60 岁，65% 女性）接受非造影 CT 检查，以评估脂肪肝、VAT 以及 CAC 和 AAC。脂肪肝通过肝脏衰减（LA；低LA=高脂肪肝）来测量。 Agatston评分用于量化钙化动脉斑块的量，钙化动脉斑块的存在定义为Agatston评分>0。在逻辑回归模型中检查了 LA 和 VAT 与 CAC 和 AAC 的横截面关联。结果：在年龄性别调整模型（OR 0.84，95%CI 0.7-0.9，p = 0.0001）和多变量调整模型（OR 0.89，95%CI）中，LA（每 1 个标准差 [SD] 递减）与 CAC 呈负相关。 0.8-0.9，p = 0.01）。当另外调整体重指数 (BMI)（OR 0.89，95%CI 0.8-0.9，p = 0.03）或增值税（OR 0.90，95%CI 0.8-0.9，p = 0.04）时，LA 与 CAC 之间的关联仍然存在。在年龄-性别调整模型中，腹部 VAT（每 1-SD 增量）与 CAC 呈正相关（OR 1.27，95%CI 1.2-1.4，p = 0.0001），但这种关联随着多变量调整（OR 1.10，95%CI 0.9-1.2，p = 0.09）和 LA 的额外调整而减弱（p = 0.24）或体重指数（p = 0.33）。对于 AAC，与 LA 和 VAT 的关联仅存在于年龄-性别调整模型中。最后，我们没有观察到 CAC (p = 0.18) 或 AAC (p = 0.24) 的 LA 和 VAT 之间的相互作用。结论：在非裔美国人中，脂肪肝与冠状动脉粥样硬化钙化相关，与腹部 VAT 或 BMI 无关。需要进一步研究以揭示脂肪肝对肥胖者冠状动脉粥样硬化的临床影响。 (C) 2012 Elsevier Ireland Ltd. 保留所有权利。
Objective: Both fatty liver and abdominal visceral fat (VAT) are associated with cardiometabolic risk factors. Whether fatty liver and VAT are jointly associated with coronary artery (CAC) or abdominal aortic (AAC) calcification is not clear.Methods: Jackson Heart Study (JHS) participants (n = 2884, mean age 60 years, 65% women) underwent non-contrast CT Exam for assessment of fatty liver, VAT, and CAC and AAC. Fatty liver was measured by liver attenuation (LA; low LA = high fatty liver). The Agatston score was used to quantify the amount of calcified artery plaque and the presence of calcified artery plaque was defined as Agatston score>0. Cross-sectional associations of LA and VAT with CAC and AAC were examined in logistic regression models.Results: LA (per 1-standard deviation [SD] decrement) was associated inversely with CAC in age-sex-adjusted (OR 0.84, 95%CI 0.7-0.9, p = 0.0001) and multivariable-adjusted models (OR 0.89, 95%CI 0.8-0.9, p = 0.01). The association persisted for LA with CAC when additionally adjusted for body mass index (BMI) (OR 0.89, 95%CI 0.8-0.9, p = 0.03) or VAT (OR 0.90, 95%CI 0.8-0.9, p = 0.04). Abdominal VAT (per 1-SD increment) was positively associated with CAC in age-sex-adjusted models (OR 1.27, 95%CI 1.2-1.4, p = 0.0001), but the association was diminished with multivariable adjustment (OR 1.10, 95%CI 0.9-1.2, p = 0.09) and with additional adjustment for LA (p = 0.24) or BMI (p = 0.33). For AAC, the associations with LA and VAT were only present in age-sex-adjusted models. Finally, we did not observe interactions between LA and VAT for CAC (p = 0.18) or AAC (p = 0.24).Conclusion: Fatty liver is associated with coronary atherosclerotic calcification independent of abdominal VAT or BMI in African Americans. Further investigations to uncover the clinical implications of fatty liver on coronary atherosclerosis in obesity are warranted. (C) 2012 Elsevier Ireland Ltd. All rights reserved.