Glycerophosphoethanolamine concentration is elevated in brain of patients with dominantly inherited olivopontocerebellar atrophy.
Glycerophosphoethanolamine concentration is elevated in brain of patients with dominantly inherited olivopontocerebellar atrophy.
复制标题
显性遗传性橄榄脑桥小脑萎缩患者大脑中甘油磷酸乙醇胺浓度升高。
DOI：
10.1016/0304-3940(90)90040-g
复制
发表时间：
1990
影响因子：
2.5
通讯作者：
Schut,L
中科院分区：
文献类型：
--
作者：
Kish,SJ;Robitaille,Y;Ball,M;Gilbert,J;Deck,JH;Chang,LJ;Schut,L
We measured the concentration of glycerophosphoethanolamine (GPEA), a membrane breakdown product, in autopsied brain of 10 patients with dominantly inherited olivopontocerebellar atrophy (OPCA), a cerebellar ataxia disorder. As compared with the controls, mean GPEA levels were significantly elevated by 37–69% in 11 of the 15 brain areas examined, including extracerebellar brain regions in which no neuronal cell loss could be detected by semiquantitative estimation. Our data suggest the possibility of altered membrane phospholipid metabolism in OPCA which could be a contributing factor in the neuronal cell death.
