Comparative study on the pregnancy outcomes of in vitro fertilization-embryo transfer between long-acting gonadotropin-releasing hormone agonist combined with transvaginal ultrasound-guided cyst aspiration and long-acting gonadotropin-releasing hormone agonist alone
Comparative study on the pregnancy outcomes of in vitro fertilization-embryo transfer between long-acting gonadotropin-releasing hormone agonist combined with transvaginal ultrasound-guided cyst aspiration and long-acting gonadotropin-releasing hormone agonist alone
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DOI：
10.1016/j.cct.2012.07.009
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发表时间：
2012-11-01
影响因子：
2.2
通讯作者：
Sun, Ying-pu
中科院分区：
文献类型：
--
作者：
Guo, Yi-hong;Lu, Na;Sun, Ying-pu
目的：回顾性分析长效促性腺激素释放激素激动剂（GnRH-a）联合经阴道超声引导囊肿抽吸对卵巢子宫内膜异位症不孕症患者体外受精-胚胎移植（IVF-ET）妊娠结局的影响。方法：134例卵巢子宫内膜异位症患者行GnRH-a联合经阴道超声引导囊肿抽吸和IVF-ET作为实验组。102例经GnRH-a和IVF-ET治疗的卵巢子宫内膜异位症患者作为对照组。治疗后比较两组患者的囊肿大小、促卵泡激素（FSH）、黄体生成素（LH）、雌二醇（E2）、取卵数、受精率、卵裂率、优质胚率、着床率、临床妊娠率及流产率。结果：试验组134例患者中，经GnRH-a联合3次经阴道超声引导下的囊肿抽吸后，138例囊肿消失。对照组102例，114个囊肿中，经GnRH-a治疗后34个囊肿消失，67个囊肿变小，13个囊肿不变。实验组流产率明显低于对照组。HCG日血清E2水平、14mm及以上卵泡数、取出卵母细胞数、优质胚率、着床率及临床妊娠率实验组均高于对照组（P < 0.05）
Objective: To retrospectively analyze the effects of long-acting gonadotropin-releasing hormone agonist (GnRH-a) combined with transvaginal ultrasound-guided cyst aspiration on the pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET) in the infertile patients with ovarian endometriosis.Methods: The 134 patients with ovarian endometriosis who underwent GnRH-a combined with transvaginal ultrasound-guided cyst aspiration and IVF-ET were served as experimental group. The 102 patients with ovarian endometriosis who underwent GnRH-a and IVF-ET were served as control group. After treatment, the cyst size, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), number of ovum pick-up, fertility rate, cleavage rate, high-quality embryo rate, implantation rate, clinical pregnancy rate and abortion rate were compared between the two groups.Results: In the 134 patients of experimental group, 138 cysts disappeared after GnRH-a combined with three times of transvaginal ultrasound-guided cyst aspiration. In the 102 patients of control group, of the 114 cysts, 34 disappeared after GnRH-a, 67 were decreased and 13 were unchanged. The abortion rate was significantly lower in experimental group than in control group. The level of serum E2 on HCG day, the number of ovarian follicles with 14 mm or more, the number of retrieved oocytes, high-quality embryo rate, implantation rate and clinical pregnancy rate were higher in experimental group than in control group (all P