Aerosol deposition in the nose as a function of body size.
Aerosol deposition in the nose as a function of body size.
复制标题
鼻子中的气溶胶沉积量与身体尺寸有关。
DOI：
10.1097/00004032-198907001-00039
复制
发表时间：
1989
期刊：
影响因子：
2.2
通讯作者：
Mautz,WJ
中科院分区：
文献类型：
--
作者：
Phalen,RF;Oldham,MJ;Mautz,WJ
人体大小对吸入气溶胶的鼻剂量的影响尚未在人体中直接测量。两种基本类型的计算模型用于计算成人吸入颗粒物沉积。一种类型使用结合颗粒空气动力学直径和平均气流速率的撞击参数。第二种类型使用鼻压降和颗粒空气动力学直径。虽然这两种类型的模型已被调整，以提供合理准确的沉积效率为成人，他们预测非常不同的沉积效率时，他们被应用于幼儿。这并不奇怪，因为气流型模型不像压降型模型那样具有与车身尺寸相关的参数。我们的研究的目的是测试这两种类型的计算模型，使用两种尺寸的理想化中空鼻模型，代表成人和幼儿。结果表明，压降关系与气溶胶沉降数据拟合得很好。当在鼻腔剂量计算中使用适当缩放的生理气流和分钟通气量时，可以看到幼儿的鼻腔剂量可能比成人的更大。
The effect of body size on nasal doses from inhaled aerosols has not been measured directly in people. Two basic types of computational models are used to calculate inhaled particle deposition in adults. One type uses an impaction parameter that incorporates particle aerodynamic diameter and the average airflow rate. The second type uses the nasal pressure drop and particle aerodynamic diameter. Although both types of models have been adjusted to give reasonably accurate deposition efficiencies for adults, they predict very different deposition efficiencies when they are applied to young children. This is not surprising because the airflow-type model has no body-sizedependent parameters, unlike the pressure-drop-type model. The objective of our studies was to test these two types of computational models using idealized hollow nasal models of two sizes, representing the adult and young child. The results indicate that a pressure-drop relationship fits the aerosol deposition data very well. When the properly scaled physiological air flows and minute ventilations are used in a nasal dose calculation, the young child is seen to have potentially larger nasal doses than those of an adult.