Xanthorrhizol, a natural sesquiterpenoid from Curcuma xanthorrhiza, has an anti-metastatic potential in experimental mouse lung metastasis model
Xanthorrhizol, a natural sesquiterpenoid from Curcuma xanthorrhiza, has an anti-metastatic potential in experimental mouse lung metastasis model
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DOI：
10.1016/j.bbrc.2004.11.020
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发表时间：
2005-01-07
影响因子：
3.1
通讯作者：
Park, KK
中科院分区：
文献类型：
--
作者：
Choi, MA;Kim, SH;Park, KK
黄毒醇是从姜黄根茎中分离得到的倍半萜类化合物。本研究通过小鼠体内肺转移模型和肿瘤团块形成实验来评价黄菌根醇的抗转移活性。有趣的是，黄菌根醇显著抑制肺组织中肿瘤结节的形成和腹腔内肿瘤肿块的形成。接下来，为了研究黄菌根醇在小鼠肺转移中的抗转移作用机制，我们利用肿瘤结节肺组织评估了几种细胞内信号分子的表达模式。与对照组相比，转移组中环氧化酶-2 （COX-2）、基质金属蛋白酶-9 （MMP-9）和磷酸化细胞外信号调节激酶（ERK）的表达水平较高，但经黄菌根醇处理后这些表达水平减弱。综上所述，黄菌根醇在体内具有抗转移活性，其作用可能与ERK、COX-2、MMP-9等与转移相关的多重信号通路密切相关。(C) 2004爱思唯尔公司版权所有。
Xanthorrhizol is a sesquiterpenoid compound isolated from the rhizome of Curcuma xanthorrhiza. In this study, the anti-metastatic activity of xanthorrhizol was evaluated by using an in vivo mouse lung metastasis model and a tumor mass formation assay. Interestingly, xanthorrhizol dramatically inhibited the formation of tumor nodules in the lung tissue and the intra-abdoininal tumor mass formation. Next, to examine the mechanism of the anti-metastatic action of xanthorrhizol in the mouse lung metastasis, expression patterns of the several intracellular signaling molecules were evaluated using the lung tissues with tumor nodules. Higher expression levels of cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), and phosphorylated extracellular signal-regulated kinase (ERK) were observed in the metastatic group compared with control, but these were attenuated by the treatment of xanthorrhizol. In conclusion, xanthorrhizol exerts anti-metastatic activity in vivo and this effect could be highly linked to the metastasis-related multiplex signal pathway including ERK, COX-2, and MMP-9. (C) 2004 Elsevier Inc. All rights reserved.