Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma
Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma
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DOI：
10.1038/s41598-020-63060-1
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发表时间：
2020-04-10
影响因子：
4.6
通讯作者：
Nonomura, Norio
中科院分区：
文献类型：
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作者：
Kawashima, Atsunari;Kanazawa, Takayuki;Nonomura, Norio
同时评估CD8 T细胞和CD4 T细胞表达的临床重要性是很重要的，因为它们在肿瘤靶向免疫反应中具有关键的网络。在97例RCC患者中，基于PD-1和TIM-3表达水平的CD8和CD4 T细胞的RNA测序和基因集富集分析表明，PD-1+TIM-3+ CD8 T细胞和PD-1lowTIM-3+CD4 T细胞的群体分别为耗竭型CD8 T细胞和调节性CD4 T细胞。这些CD4和CD8 T细胞群在WHO/ISUP分级较高的RCC患者中显著上调（3、4级）
It is important to evaluate the clinical importance of both CD8 T cells and CD4 T cells expression simultaneously because they have crucial networks in tumour targeting immune responses. In 97 RCC patients, RNA sequencing and gene set enrichment analysis of both CD8 and CD4 T cells based on the expression levels of PD-1 and TIM-3 implied that the populations of PD-1+TIM-3+ CD8 T cells and PD-1lowTIM-3+CD4 T cells were characterized as exhausted CD8 T cells and regulatory CD4 T cells, respectively. These populations of CD4 and CD8 T cells were significantly upregulated in the patients with RCC of higher WHO/ISUP grade (grades 3, 4) (P