Cancer cell membrane-coated gold nanorods for photothermal therapy and radiotherapy on oral squamous cancer
Cancer cell membrane-coated gold nanorods for photothermal therapy and radiotherapy on oral squamous cancer
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癌细胞膜包被的金纳米棒用于口腔鳞癌的光热治疗和放射治疗
DOI：
10.1039/d0tb01063d
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发表时间：
2020-08-28
影响因子：
7
通讯作者：
Wu, Mengjie
中科院分区：
文献类型：
--
作者：
Sun, Qiang;Wu, Jinggen;Wu, Mengjie
不同治疗方法的结合极大地提高了每种治疗方法的抗癌效果，结合了它们的优点，在临床翻译中显示出良好的潜力。在这里，我们制备了癌细胞膜包覆的金纳米棒(GNR@Mem)，它在第二近红外窗口具有良好的光热传递能力，在X射线照射下具有辐射增敏能力。癌细胞膜涂层赋予了纳米药物在生理环境中的稳定性和体外对特定癌细胞的选择性同型靶向性。在近红外光和X射线照射下，金纳米棒引起温度升高，产生活性氧，进而破坏DNA螺旋结构，导致细胞凋亡增加。由于其较长的血液循环时间和同型靶向作用，GNR@Mem的肿瘤蓄积显著增加。活体结果表明，光热治疗和放射治疗相结合可有效抑制肿瘤生长，且无明显的全身毒性。
The combination of different modalities greatly enhances the anticancer efficacy of each treatment by combining their merits, showing promising potential in clinical translation. Herein, we fabricated cancer cell membrane-coated gold nanorods (GNR@Mem) possessing excellent photothermal transfer ability in the second near-infrared window and radiosensitizing ability under X-ray irradiation. The cancer cell membrane coating endowed the nanomedicine with stability in the physiological environment and selective homotypic targeting to specific cancer cellsin vitro. Under NIR light and X-ray irradiation, the gold nanorods induced a temperature increase, reactive oxygen generation, and subsequent damage to the DNA helix structure, leading to enhanced cell apoptosis. Benefitting from its relative long circulation time in the blood and homotypic targeting effect, the tumor accumulation of GNR@Mem significantly increased. Thein vivoresults demonstrate that the combination of photothermal therapy and radiotherapy effectively suppresses tumor growth without noticeable systemic toxicity.