Faecal calprotectin: a marker of inflammation throughout the intestinal tract
Faecal calprotectin: a marker of inflammation throughout the intestinal tract
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DOI：
10.1097/00042737-200208000-00002
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发表时间：
2002-08-01
影响因子：
2.1
通讯作者：
Fagerhol, MK
中科院分区：
文献类型：
--
作者：
Aadland, E;Fagerhol, MK
只有少部分腹部不适的患者存在器质性病变，但通过简单的临床检查很少能做出正确的诊断。必须采用额外的诊断程序，但这些程序昂贵且要求较高，并且具有一定的风险。对粪便中中性粒细胞衍生蛋白钙卫蛋白浓度的评估可用作筛查测试（“肠道ESR”），以选择患者进行进一步检查。该测试可以对 1-2 克随机粪便样本进行，这些样本可以通过普通邮件发送到实验室，因为粪便中的蛋白质非常稳定。该测试对胃肠道癌症和炎症性肠病（IBD）具有高敏感性和特异性。粪便钙卫蛋白水平反映了 IBD 的疾病活动性，可用于监测治疗反应并检测复发。 (C) 2002 年利平科特·威廉姆斯·威尔金斯。
Only a small proportion of patients with abdominal discomfort have organic disease, but a correct diagnosis can seldom be made by simple clinical examination. Additional diagnostic procedures must be employed, but these are expensive and demanding and carry a certain risk. Assessment of faecal concentrations of the neutrophil granulocyte-derived protein calprotectin can be used as a screening test - an 'ESR of the gut' - to select patients for further examination. The test can be performed on 1-2 g of random stool samples that can be sent to the laboratory by ordinary mail since the protein is remarkably stable in stools. The test has high sensitivities and specificities for gastrointestinal cancers and inflammatory bowel disease (IBD). Faecal calprotectin levels reflect the disease activity in IBD and can be used to monitor the response to treatment and detect relapses. (C) 2002 Lippincott Williams Wilkins.