Crossover interference in humans
Crossover interference in humans
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DOI：
10.1086/376610
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发表时间：
2003-07-01
影响因子：
9.8
通讯作者：
Stahl, FW
中科院分区：
文献类型：
--
作者：
Housworth, EA;Stahl, FW
同源染色体之间的互换有助于减数分裂I期间染色体的适当分离。在许多生物体中，互换所必需的基因功能也有助于紧密的染色体配对，称为“突触”。许多生物--包括萌芽酵母、人类、斑马鱼、果蝇和拟南芥--调节着交叉的分布，因此，大多数情况下，每个染色体束至少会发生一次交叉，而每条染色体的平均交叉次数仍然很少。这一规则是通过交叉干扰获得的。最近的证据表明，利用重组功能实现突触的有机体有两类交叉，其中只有一类受到干扰。我们在CEPH数据中对这一双途径假说进行了统计检验，并在人类身上找到了支持双途径假说的证据。
Crossing-over between homologous chromosomes facilitates proper disjunction of chromosomes during meiosis I. In many organisms, gene functions that are essential to crossing-over also facilitate the intimate chromosome pairing called "synapsis." Many organisms - including budding yeast, humans, zebrafish, Drosophila, and Arabidopsis regulate the distribution of crossovers, so that, most of the time, each chromosome bundle gets at least one crossover while the mean number of crossovers per chromosome remains modest. This regulation is obtained through crossover interference. Recent evidence suggests that the organisms that use recombination functions to achieve synapsis have two classes of crossovers, only one of which is subject to interference. We statistically test this two-pathway hypothesis in the CEPH data and find evidence to support the two-pathway hypothesis in humans.