Effects of intravenous anesthesia with propofol on regional cortical blood flow and intracranial pressure in surgery for moyamoya disease
Effects of intravenous anesthesia with propofol on regional cortical blood flow and intracranial pressure in surgery for moyamoya disease
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DOI：
10.1016/j.surneu.2006.11.064
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发表时间：
2007-10-01
影响因子：
--
通讯作者：
Hashimoto, Nobuo
中科院分区：
文献类型：
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作者：
Kikuta, Ken-ichiro;Takagi, Yasushi;Hashimoto, Nobuo
背景：本研究的目的是比较七氟烷吸入麻醉和异丙酚静脉麻醉对MMD患者血运重建手术中ICP和rCoBF的影响。方法：1999年至2004年间，共对58名患者进行了90例血运重建手术。其中，在14名患者的连续20次手术中，使用ICP监测探头对ICP进行了连续监测。随后，在9名患者（CoBF组）的连续14次手术中，用激光多普勒流量计探头进行了rCoBF的术中监测。麻醉药由1.5%~2.5%七氟烷改为6 mg/kg/小时异丙酚后，进行ICP和rCoBF监测20分钟以上。在所有病例中，这些患者的PaCO2在整个手术过程中均严格维持在38至40 mm Hg之间。结果：在ICP组和CoBF组中，吸入麻醉下获得的生理参数值与静脉麻醉下获得的生理参数值没有统计学差异。异丙酚麻醉下ICP值显着低于七氟醚麻醉下（P
Background: The aim of this study was to compare the effects of inhalation anesthesia with sevoflurane and intravenous anesthesia with propofol on ICP and rCoBF during revascularization surgery for patients with MMD.Methods: Between 1999 and 2004, a total of 90 revascularization surgeries were performed on 58 patients. Among them, in 20 consecutive operations on 14 patients, continuous monitoring of ICP was performed with an ICP monitoring probe. Subsequently, in 14 consecutive operations on 9 patients (CoBF group), intraoperative monitoring of rCoBF was carried out with a laser Doppler flowmeter probe. The monitoring of ICP and rCoBF was performed for more than 20 minutes after the administration of anesthetic was changed from 1.5% to 2.5% sevoflurane to 6 mg/kg per hour of propofol. In all cases, the PaCO2 of these patients was strictly maintained between 38 and 40 mm Hg throughout the operations.Results: In both the ICP and the CoBF groups, the values of physiologic parameters obtained under inhalation anesthesia did not differ statistically from those obtained under intravenous anesthesia. The value for ICP under anesthesia with propofol was significantly lower than that under anesthesia with sevoflurane (P