Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl-LiCl
Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl-LiCl
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DOI：
10.1021/ol0625536
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发表时间：
2006-11-23
期刊：
影响因子：
5.2
通讯作者：
Knochel, Paul
中科院分区：
文献类型：
--
作者：
Lin, Wenwei;Baron, Oliver;Knochel, Paul
以OBoc为导向基团，以TMPMgCl-LiCl为碱，可以很容易地进行含酯、腈或酮的高功能化芳烃的直接镁化反应。例如，它允许在bbb95 %中制备间镁化二苯甲酮。猝灭后得到高功能化取代苯。
The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl-LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in > 95%. After quenching, highly functionalized and substituted benzenes are obtained.