Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling
Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling
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DOI：
10.1038/jhh.2009.57
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发表时间：
2010-03-01
影响因子：
2.7
通讯作者：
Miyachi, M.
中科院分区：
文献类型：
--
作者：
Gando, Y.;Kawano, H.;Miyachi, M.
动脉硬化、高血压和左心室重构与心血管疾病风险增加相关。心肺健康与心血管功能和降低心血管疾病风险相关。这项横断面研究的目的是确定女性心肺健康、动脉僵硬度、血压 (BP) 和左室重构之间的关系。根据峰值摄氧量，共有 159 名绝经前（年轻）和绝经后（老年）女性被分为低（不健康）或高（健康）心肺健康组。通过臂踝脉搏波速度（baPWV）、颈动脉增强指数（AI）和左心室相对壁厚（RWT）来测量动脉僵硬度和左心室重塑。双向方差分析表明，年龄与 baPWV、颈动脉 AI、BP 和 RWT 心肺健康之间存在显着交互作用。在老年组中，动脉僵硬度（baPWV；1401 +/- 231 vs 1250 +/- 125cms(-1)，P
Arterial stiffening, hypertension and left ventricular (LV) remodelling are associated with increased risk of cardiovascular disease. Cardiorespiratory fitness is associated with cardiovascular function and reduced risk of cardiovascular disease. This cross-sectional study was carried out to determine the relationships between cardiorespiratory fitness, arterial stiffness, blood pressure (BP) and LV remodelling in women. On the basis of peak oxygen uptake, a total of 159 premenopausal (young) and postmenopausal (older) women were categorized into either low (unfit) or high (fit) cardiorespiratory fitness groups. The arterial stiffness and LV remodelling were measured by brachial-ankle pulse wave velocity (baPWV) and carotid augmentation index (AI) and LV relative wall thickness (RWT). Two-way analysis of variance indicated a significant interaction between age and cardiorespiratory fitness in baPWV, carotid AI, BP and RWT. In the older group, arterial stiffness (baPWV; 1401 +/- 231 vs 1250 +/- 125cms(-1), P